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EC number: 242-056-0
CAS number: 18171-19-2
1: Dissolved organic carbon (DOC) concentration (mg/l) and calculated %
biodegradation for inoculum blank, test substance and reference substance
Inoculum Blank (mean of two replicates with duplicate analyses)
Test sample Replicate 1 (mean of two analyses)
Test sample Replicate 2 (mean of two analyses)
Reference substance Replicate 1 (mean of two analyses)
Reference substance Replicate 2 (mean of two analyses)
Biodegradation in water: screening
tests: 56% in 28 days (EU Method C.4-A), read-across from an analogous
substance. No significant biodegradation of the silanol hydrolysis
product is expected.
There are no reliable ready
biodegradation data available for 3-chloropropyl(dimethoxy)methylsilane,
therefore good quality data for the analogous substance,
3-chloropropyl(diethoxy)methylsilane (CAS 13501-76-3) have been read
across. Both substances share the same silanol hydrolysis product,
3-chloropropyl(methyl)silanediol; the other hydrolysis products being
methanol and ethanol respectively. In view of the rapid hydrolysis, it
is the silanol hydrolysis product that is relevant for environmental
Ethanol and methanol are readily
biodegradable (OECD 2004a and OECD 2004b).
and 3-chloropropyl(diethoxy)methylsilane are within an analogue group of
substances within which in general, there is no evidence of any
significant biodegradation once hydrolysis and subsequent
biodegradation of alkoxy/acetoxy groups has been taken into account.
This wider analogue group for the
ready biodegradability endpoint consists of substances containing a
number of different functional groups but specific read-across is
between substances with similar functionality.
The table below presents
ready biodegradation data available for substances relevant to
It is therefore considered
valid to read-across the result for 3-chloropropyl(diethoxy)methylsilane
to fill the data gap for the registered substance since both substances
generate the same silanol hydrolysis product.
Additional information is given in
a supporting report (PFA, 2013f) attached in Section 13.
Table : Ready biodegradation data
available for relevant substances
Readily biodegradable? Yes/no
Result: Biodegradation after 28 day
Corrected % biodegradation once alkoxy/acetoxy biodegradation is accounted for
OECD 301 B
The negative values in this
column are where the biodegradation rate observed in the test is less
than that expected assuming only alkoxy/acetoxy parts biodegrade. This
could be due to low solubility of parent substance or low rates of
hydrolysis. These values should in effect be considered as zero.
In the study with
3-chloropropyl(diethoxy)methylsilane (CAS 13501-76-3), a biodegradation
of 56% in 28 days was determined in a reliable study conducted according
to an appropriate test protocol, and in compliance with GLP (EU Method
C.4-A). 3-Chloropropyl(diethoxy)methylsilane (CAS 13501-76-3) hydrolyses
within the timescale of the ready biodegradation study to form
3-chloropropyl(methyl)silanediol and ethanol.
The biodegradation observed
in the study is attributable to the biodegradation of the ethanol
biodegradation is expected for the silanol hydrolysis product.
OECD (2004a): SIDS Initial
Assessment Report for SIAM 19, Berlin, Germany, 18-20 October 2004,
Methanol, CAS 67-56-1.
OECD (2004b): SIDS Initial
Assessment Report for SIAM 19, Berlin, Germany, 19-22 October 2004,
Ethanol, CAS 64-17-5.
PFA (2013f). Peter Fisk
Associates, Biodegradation Main Analogue Group report, PFA.300.005.007
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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