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EC number: 232-218-9 | CAS number: 7790-69-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1997-06-13 to 1997-12-23
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 1984
- Deviations:
- no
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- Samples were analyzed for lithium in triplicate using a FLM-AAS method developed and validated by the FMC Corporation. Measured concentrations of lithium chloride were calculated by multiplying measured lithium concentrations by 14.427.
- Vehicle:
- no
- Details on test solutions:
- Test solutions were prepared by adding the appropriate amounts of lithium chloride (0.0641, 0.1240, 0.2493, 0.5006 and 0.9923 g) directly to five 1 L volumes of dilution water. The resulting nominal concentrations were 64.1, 124, 249, 501, 992 mg LiCl/L. A dilution water control was maintained concurrently with the test solutions.
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- Water fleas will be neonates (i.e. <24 hours old) obtained by isolating gravid females from the culture water in food-free dilution water < 24 hours prior to beginning the test.
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- No
- Hardness:
- c(CaCO3) = 82 mg/L
- Test temperature:
- 19.4 to 20.8 °C
- pH:
- At test initiation: pH 7.1 to 8.6
Remainder of the test: pH 7.0 to 7.1 - Dissolved oxygen:
- at test initiation: 9.3 mg/L (100 % of saturation)
remainder of the test: 8.4 to 8.9 mg/L (94 to 98 % of saturation) - Nominal and measured concentrations:
- Nominal concentrations: control, 64.1, 124, 249, 501 and 992 mg LiCl/L
Measured concentrations: 0.0, 63.4, 123, 249, 501 and 978 mg LiCl/L - Reference substance (positive control):
- no
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 249 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Remarks:
- LiCl
- Basis for effect:
- mobility
- Remarks on result:
- other: 95% CL: 197 and 315 mg/L
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 63.4 mg/L
- Nominal / measured:
- meas. (geom. mean)
- Conc. based on:
- test mat.
- Remarks:
- LiCl
- Basis for effect:
- mobility
- Details on results:
- The 48-hour EC50 was 249 mg/L (based on mean measured concentrations) with 95 % confidence limits of 197 and 315 mg/L. The NOEC was 63.4 mg/L.
- Results with reference substance (positive control):
- No reference substance
- Reported statistics and error estimates:
- The EC50 values were estimated by a computer program (Wheat, 1989) using the following statistical methods: moving average angle, probit, logit, and non-linear interpolation. Confidence limits for EC50 values determined by non-linear interpolation were calculated by binomial probability. The method selected for reporting the test results was determined by the characteristics of the data, i.e. the presence or absence of 0 % and 100 % mortality and the number of concentrations in which mortalities between 0 and 100 % occurred.
- Validity criteria fulfilled:
- yes
- Conclusions:
- The 48-hour EC50 in Daphnia magna was 249 mg lithium chloride/L (based on mean measured concentrations) with 95 % confidence limits of 197 and 315 mg wm/L. The NOEC was 63.4 mg lithium chloride/L.
- Executive summary:
A short-term toxicity test on daphnia with lithium nitrate is not available. Consequently, read-across was applied using study results from lithium chloride.
A static freshwater toxicity test was conducted to determine the acute toxicity of lithium chloride to the water flea, Daphnia magna according to OECD Guideline 202. Mean measured concentrations of lithium chloride ranged from 63.4 to 978 mg/L and from 99 to 109 % of nominal. All test solutions appeared clear and colourless and concentrations remained stable throughout the test. Mortality of the water flea exposed for 48 hours to lithium chloride ranged from 5 % at test concentrations ≤ 123 mg/L to 100 % at greater than or equal to 501 mg/L. One water flea in 63.4 mg/L died as a result of becoming physically stuck to the wall of the test chamber and was not chemically related. Control mortality was 0 %. The 48-hour EC50 was 249 mg/L with 95 % confidence limits of 197 and 315 mg/L. The NOEC was 63.4 mg/L (Toxikon, 1997).
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Only handbook or published data was available. Guideline was not indicated.
- GLP compliance:
- no
- Analytical monitoring:
- not specified
- Vehicle:
- not specified
- Test organisms (species):
- Daphnia magna
- Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
- Details on test conditions:
- TEST SYSTEM
- Type: open - Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- ca. 3 581 mg/L
- Conc. based on:
- test mat.
- Conclusions:
- In this static 48-h acute toxicity test with Daphnia magna a LC50 of 3581 mg/L for sodium nitrate was determined.
- Executive summary:
A static freshwater toxicity test was conducted to determine the acute toxicity of sodium nitrate to the water flea, Daphnia magna. A 48-h LC50 of 3581 mg/L was determined for sodium nitrate.
Referenceopen allclose all
Description of key information
The 48-hour EC50 in Daphnia magna was 249 mg lithium chloride/L (based on mean measured concentrations) with 95 % confidence limits of 197 and 315 mg wm/L. The NOEC was 63.4 mg lithium chloride/L. Based on read-across approach a 48-hour EC50 of 405 mg/L could be calculated for lithium nitrate.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 405 mg/L
Additional information
Key study
A short-term toxicity test on daphnia with lithium nitrate is not available. Consequently, read-across was applied using study results from lithium chloride.
A static freshwater toxicity test was conducted to determine the acute toxicity of lithium chloride to the water flea, Daphnia magna according to OECD Guideline 202. Mean measured concentrations of lithium chloride ranged from 63.4 to 978 mg/L and from 99 to 109 % of nominal. All test solutions appeared clear and colourless and concentrations remained stable throughout the test. Mortality of the water flea exposed for 48 hours to lithium chloride ranged from 5 % at test concentrations ≤ 123 mg/L to 100 % at greater than or equal to 501 mg/L. One water flea in 63.4 mg/L died as a result of becoming physically stuck to the wall of the test chamber and was not chemically related. Control mortality was 0 %. The 48-hour EC50 was 249 mg/L with 95 % confidence limits of 197 and 315 mg/L. The NOEC was 63.4 mg/L. (Toxikon, 1997)
Based on read-across approach a 48-hour EC50 of 405 mg/L could be calculated for lithium nitrate.
Supporting data
A static freshwater toxicity test was conducted to determine the acute toxicity of sodium nitrate to the water flea, Daphnia magna. A 48-h LC50 of 3581 mg/L was determined for sodium nitrate. (Dowden et al., 1965)
Based on read-across approach a LC50 of 2612 mg/L was calculated for lithium nitrate.
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