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EC number: 200-652-8 | CAS number: 67-43-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- ca. 1983
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: No data on batch number and composition; basic data given, comparable to guidelines/standards
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Principles of method if other than guideline:
- Method used described in 'Appraisal of the safety of chemicals in foods, drugs and cosmetics', by the staff of the division of
pharmacology, food and drug administration. Primary irritation score by J.H. Draize (1959).
Test substance was also tested on abraded skin. - GLP compliance:
- not specified
Test material
- Reference substance name:
- Pentasodium (carboxylatomethyl)iminobis(ethylenenitrilo)tetraacetate
- EC Number:
- 205-391-3
- EC Name:
- Pentasodium (carboxylatomethyl)iminobis(ethylenenitrilo)tetraacetate
- Cas Number:
- 140-01-2
- IUPAC Name:
- pentasodium 2,2',2'',2''',2''''-(ethane-1,2-diylnitrilo)pentaacetate
- Details on test material:
- Yellow turbid liquid, supplied by Akzo Chemie LW, Amersfoort, the Netherlands
Test substance was applied undiluted.
pH value: 12.53
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: not indicated
- Age at study initiation: not indicated
- Weight at study initiation: 2.4-2.6 kg
- Housing: individually
- Diet (e.g. ad libitum): ad lib
- Water (e.g. ad libitum): ad lib
- Acclimation period: not indicated
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ± 1
- Humidity (%): 45-55
- Air changes (per hr): not indicated.
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: not indicated.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: shaved and one side also abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml
- Concentration (if solution): undiluted - Duration of treatment / exposure:
- 4 h
- Observation period:
- up to 72 h
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: on the back
- % coverage: two squares of 2.5 cm
- Type of wrap if used: patches consisted of double layer light gauze; the trunks was wrapped in a rubber sleeve and the animals were immobilized in restrainers
REMOVAL OF TEST SUBSTANCE
- Washing (if done): not indicated
- Time after start of exposure: 4 hours
SCORING SYSTEM: according to Draize (1959). Readings were made immediately after removal of the patches, and 24 and 72
hours thereafter. The cumulative scores 4/24 hours and 72 hours (erythema and oedema) were averaged for bot abraded and
intact skin and added together to calculate the primary irritation index.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 4/24 hours and 72 hours
- Score:
- 0
- Reversibility:
- other: no irritation at all
- Remarks on result:
- other: all 3 animals had score: 0
- Irritant / corrosive response data:
- No irritation
- Other effects:
- Not indicated
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test substance is not a skin irritant
- Executive summary:
- A study was performed to assess the irritancy potential of the test material to the skin of the New Zealand White rabbit. The method used was essentially according to the recommendations of the OECD Guidelines for Testing of Chemicals No. 404 "Acute Dermal Irri tation/Corrosion" A single 4 -hour, occluded application of the test material to intact and abraded skin of three rabbits produced no erythema or oedema. All treated skin sites appeared normal at the 4/24 -hour and 72 -hour observation. The test material produced a primary irritation index of 0.0 and was classified as a non-irritant to rabbit skin according to the Draize classification scheme. No corrosive effects were noted. The test material did not meet the criteria for classification as irritant or corrosive according to OECD-GHS labeling regulations. No symbol and risk phrase are required.
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