Registration Dossier
Registration Dossier
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EC number: 500-031-4 | CAS number: 9051-51-8 1 - 4.5 moles propoxylated
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 2,2'-Oxydiethanol, propoxylated
- EC Number:
- 500-031-4
- EC Name:
- 2,2'-Oxydiethanol, propoxylated
- Cas Number:
- 9051-51-8
- Molecular formula:
- C4 H10 O3 (C3 H6 O) n, where n average >1 and n<4.5
- IUPAC Name:
- 2,2'-Oxydiethanol, propoxylated
- Details on test material:
- - Physical state: Liqiud
- content: > 99%
- chemical name: 2,2´-Oxydiethanol, propoxylated (>1>4,5 mol PO)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Crl: KBL(NZW)BR
- Details on test animals or test system and environmental conditions:
- according to guideline
sex of the test animals: female
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The surrounding untreated skin served as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 1, 24, 48 and 72 hours after patch removal. If dermal irritation was observed, additional monitoring on day 7 and 14 after patch removal was done.
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 2.5 cm
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: #1-#3
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal: #1-#3
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0
- Max. score:
- 4
- Other effects:
- There were no systemic intolerance reactions.
Applicant's summary and conclusion
- Executive summary:
An acute dermal irritation/corrosion test (OECD 404) was performed with Diethyleneglycol, propoxylated. According to classification criteria Diethyleneglycol, propoxylated is not an irritant to the skin. There were no systemic intolerance reactions.
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