Registration Dossier
Registration Dossier
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EC number: 211-254-9 | CAS number: 636-30-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study complies to general scientific principles; pre-dates GLP regulations, short report, few methodological details
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
- Principles of method if other than guideline:
- Single dermal application, no detail regarding duration, site or vehicle
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2,4,5-trichloroaniline
- EC Number:
- 211-254-9
- EC Name:
- 2,4,5-trichloroaniline
- Cas Number:
- 636-30-6
- Molecular formula:
- C6H4Cl3N
- IUPAC Name:
- 2,4,5-trichloroaniline
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Temperature: 22 C
- humidity: 55-65 % rel.
- light/dark : 12h / 12h
- 5 animals per cage
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- no data
- Doses:
- 1000 or 2500 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- not required
- Details on study design:
- necropsy performed on selected animals only
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 1 000 - < 2 500 mg/kg bw
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
- Mortality:
- at 2500 mg/kg bw 1 of 5 animals each died in the male and the female groups
- Clinical signs:
- other: 2500 mg/kg bw: general well-being rduced, sedation in all animals on the day of treatment
- Gross pathology:
- no findings
Any other information on results incl. tables
a dose of 1000 mg/kg did not cause any adverse findings after dermal exposure
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The LD50 after dermal exposure of rats was above 2500 mg/kg bw. The NOEL was 1000 mg/kg bw.
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