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Diss Factsheets
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EC number: 913-888-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Dose descriptor:
- NOAEL
- 1 500 mg/kg bw/day
Additional information
No reliable studies with ammonium dihydrogenorthophosphate are present. In an OECD 422 study rats (10/sex/dose) were dosed with 250, 750 and 1500 mg/kg bw/day diammonium hydrogenorthophosphate orally via gavage. Males were treated until termination during week 6 of treatment. Doses were administered to the females for two weeks prior to pairing, throughout pairing and gestation until Day 3 of lactation. No effects on reproduction parameters were observed up to the highest dose tested. Therefore, the NOAEL is considered to be =1500 mg/kg bw/day.
In accordance with REACH Annex XI section 1, no further studies are considered necessary. Ammonium dihydrogenorthophosphate dissociates into NH4+ and phophate ions. Phosphate is a normal body and nutritional component and is regulated within the body. NH4+ serves a major role in the maintenance of the acid-base balance. The available data from the OECD422 study show no effects on reproduction and developmental parameters in the presence of maternal toxic effects. The lack of effects at dose levels well in excess of the NOAEL based on general toxicity suggests that ammonium dihydrogenorthophosphate is not a significant risk to the reproductive process and further studies are unlikely to show any significant effects. In addition, the World Health Organisation reports that the maximum tolerable daily intake (MTDI) of phosphates is 70 mg/kg bw (WHO TR series 683), and this value is considered to be well below that observed for reproduction/developmental toxicity. Overall, an additional study is unlikely to result in providing further evidence of reproductive/developmental toxicity as the existing data have demonstrated a lack of effect at dose levels well in excess of general toxicity and expected human exposure. Therefore, such a study is not considered necessary.
Short description of key information:
No data on ammonium dihydrogenorthophosphate is present. However, reliable data available on diammonium hydrogenorthophosphate shows a
NOAEL for reproduction toxicity after oral exposure of rats of =1500 mg/kg bw/day. Based on the toxicity profile, the properties of the NH4+ and
phosphate ions and the tolerable intake of phosphorus, the overall conclusion is that no additional studies are considered necessary.
Effects on developmental toxicity
Description of key information
No data on ammonium dihydrogenorthophosphate is present. Reliable data available on diammonium hydrogenorthophosphate shows a NOAEL for
developmental toxicity after oral exposure of rats of =1500 mg/kg bw/day. Based on the toxicity profile, the properties of the NH4+ and phosphate ions and
the tolerable intake of phosphorus, the overall conclusion is that no additional studies are considered necessary.
Effect on developmental toxicity: via oral route
- Dose descriptor:
- NOAEL
- 1 500 mg/kg bw/day
Additional information
No reliable studies with ammonium dihydrogenorthophosphate are present.
In an OECD 422 study rats (10/sex/dose) were dosed with 250, 750 and 1500 mg/kg bw/day ammonium dihydrogenorthophosphate orally via gavage. Males were treated until termination during week 6 of treatment. Doses were administered to the females for two weeks prior to pairing, throughout pairing and gestation until Day 3 of lactation. No effects on developmental parameters were observed up to the highest dose tested. Therefore, the NOAEL is considered to be =1500 mg/kg bw/day.In accordance with REACH Annex XI section 1, no further studies are considered necessary. Ammonium dihydrogenorthophosphate dissociates into NH4+ and phophate ions. Phosphate is a normal body and nutritional component and is regulated within the body. NH4+ serves a major role in the maintenance of the acid-base balance. The available data from the OECD422 study show no effects on reproduction and developmental parameters in the presence of maternal toxic effects. The lack of effects at dose levels well in excess of the NOAEL based on general toxicity suggests that ammonium dihydrogenorthophosphate is not a significant risk to the reproductive process and further studies are unlikely to show any significant effects. In addition, the World Health Organisation reports that the maximum tolerable daily intake (MTDI) of phosphates is 70 mg/kg bw (WHO TR series 683), and this value is considered to be well below that observed for reproduction/developmental toxicity. Overall, an additional study is unlikely to result in providing further evidence of reproductive/developmental toxicityas the existing data have demonstrated a lack of effect at dose levels well in excess of general toxicity and expected human exposure. Therefore, such a study is not considered necessary.
Justification for classification or non-classification
Based on the available data, the reaction mass of ammonium dihydrogenorthophosphate and diammonium hydrogenorthophosphate does not have to be classified according to Directive 67/548/EC and the CLP Regulation for reproduction and developmental toxicity.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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