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EC number: 203-694-5 | CAS number: 109-67-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16.07.1982 - 06.08.1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Fully documented, non GLP Study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- The stepwise approach from the guideline is not adopted. Only the average weight of the test animals is given, and not the weight at the beginning and end of the test.
- GLP compliance:
- no
Test material
- Reference substance name:
- Pent-1-ene
- EC Number:
- 203-694-5
- EC Name:
- Pent-1-ene
- Cas Number:
- 109-67-1
- Molecular formula:
- C5H10
- IUPAC Name:
- pent-1-ene
- Details on test material:
- - Name of test material (as cited in study report): Pentene-1
- Analytical purity: not reported
- Impurities (identity and concentrations): not reported
- Composition of test material, percentage of components: not reported
- Lot/batch No.: not reported
- Expiration date of the lot/batch: not reported
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Russian Albino
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Asta-Werke AG, D-4800 Bielefeld 14
- Age at study initiation: not reported
- Weight: 2.6 - 2.9 kg
- Housing: single
- Diet (e.g. ad libitum): Standardized feed for test animals ALTROMIN
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 1 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 1°C
- Humidity (%): 50 - 60 %
- Air changes (per hr): not reported
- Photoperiod (hrs dark / hrs light): 12h/12h
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- 0.1 ml
- Duration of treatment / exposure:
- The lids were gently held together for about one second in order to prevent loss of the material. No further indication on the exposure time was reported
- Observation period (in vivo):
- 1, 24, 48 and 72 hours
- Number of animals or in vitro replicates:
- 3 Female animals
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): No
- Time after start of exposure:
SCORING SYSTEM:
Eye changes were scored according to standard method (EU B.5.). The scores were multiplied, averaged and added according to a predefined scheme resulting in an irritation index (Draize, J.H., Woodward, G. and H.O.Calvery, J. Pharmacol. Exp. Therap., 82, 377-390, 1944 and Draize, J.H. in Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics; 46-59, Assoc. of Food and Drug Officials of the United States, Topeka, Kansas (1965)):
0-10 not irritating
11-25 slightly irritating
26-56 moderately irritating
57-110 strongly irritating
TOOL USED TO ASSESS SCORE: hand-slit lamp (model: ophthalmoskop, Fa. Heine, Type med. 261)
Results and discussion
In vivo
- Irritant / corrosive response data:
- Only short-term changes of low intensity were induced upon insertion of 1-pentene into the rabbit eye. Cornea and Iris were without reaction upon contact. The conjunctiva reacted with redness, swelling and secretion. Redness consisted of the formation of slight hyperemia with a grade of 1. They appeared for all 3 animals up to 72 h. One animal showed a slight swelling which had disappeared after 48 h. Secretion was only observed for 2 animals. This finding was observed only for 1 hour after application. The intensity reached a grade of 2.
- Other effects:
- Systemic toxicity effects were not observed.
Any other information on results incl. tables
Effects of 1 -pentene on the conjunctiva of rabbit eyes (values for cornea and iris were 0 in all cases)
exposition time (h) | reaction grade according to Draize animal No. | |||
1 | 2 | 3 | ||
redness | 1 | 1 | 1 | 1 |
24 | 1 | 1 | 1 | |
48 | 1 | 1 | 1 | |
72 | 1 | 1 | 1 | |
swelling | 1 | 0 | 1 | 0 |
24 | 0 | 1 | 0 | |
48 | 0 | 0 | 0 | |
72 | 0 | 0 | 0 | |
secretion | 1 | 1 | 2 | 0 |
24 | 0 | 0 | 0 | |
48 | 0 | 0 | 0 | |
72 | 0 | 0 | 0 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The calculated irritation index reached a value of 2.8. Hence, 1-pentene is not irritating for the eye.
- Executive summary:
For the determination of its effect on rabbit eyes, 1 -Penten was inserted into the conjunctival sac of rabbit eyes. It was applied in doses of 0.1 ml per eye. Only the conjunctiva showed low-grade changes.
The conjunctiva reacted short-term (after 1 hour) with redness, swelling and secretion. 48 h after application only slight hyperamia was observed which was declining immediately after the 72h-observation phase.
The obtained irritation score was 2.8.
1 -Pentene possesses no irritating effect on the mucous membrane of the eye.
Systemic toxicity effects were not observed.
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