Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Additional toxicological data

Currently viewing:

Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Reference
Reference Type:
publication
Title:
Patty`s Industrial Hygiene and Toxicology
Author:
Clayton GD and Clayton FE
Year:
1994
Bibliographic source:
4th ed., Vol. II, Part D, 1994

Materials and methods

Type of study / information:
other: review
Test guideline
Qualifier:
no guideline followed
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Isobutyl acrylate
EC Number:
203-417-8
EC Name:
Isobutyl acrylate
Cas Number:
106-63-8
Molecular formula:
C7H12O2
IUPAC Name:
isobutyl acrylate

Results and discussion

Any other information on results incl. tables

Isomerization appears to decrease the oral, but increase the dermal toxicity.

Isobutyl acrylate is considered only slightly irritating.

Data from an animal study have suggested the possibility of dermal sensitivity (skin sensitization).

no further details provided

Applicant's summary and conclusion