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EC number: 275-965-6 | CAS number: 71735-74-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- non GLP, body weight development not recorded, no clinical signs recorded, observation period only 3 days (effects were reversible within two days)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: "Hazardous Substances Regulations" under the U.S.A. Federal Hazardous Substances Labelling Act Sect. 191.12 (February 1965)
- Principles of method if other than guideline:
- 0.1 ml of the test compound were instilled into the conjunctival sac of the left eye of six rabbits. The eyelids were then held closed for 1 second. The right eye served as a control. After 30 seconds the compound was, as far as possible, flushed out of the eyes of three of the rabbits with approximately 200 ml. of warm water. The rabbits were examined 1, 24, 48 and 72 hours after application.
- GLP compliance:
- no
Test material
- Reference substance name:
- Ethyl 3-[[bis(1-methylethoxy)phosphinothioyl]thio]propionate
- EC Number:
- 275-965-6
- EC Name:
- Ethyl 3-[[bis(1-methylethoxy)phosphinothioyl]thio]propionate
- Cas Number:
- 71735-74-5
- Molecular formula:
- C11H23O4PS2
- IUPAC Name:
- ethyl 3-{[bis(propan-2-yloxy)(sulfanylidene)-λ⁵-phosphanyl]sulfanyl}propanoate
- Details on test material:
- - Physical state: liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 12-14 weeks
- Weight at study initiation: males: 2.32 kg; females: 2.57
- Housing: individually
- Diet: commercial irradiated diet (Styles-Oxoid) ad libitum
- Water: Sterile filtered water, ad libitum
- Acclimation period: 1 week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/- 1
- Humidity (%): 50-70
- Photoperiod (hrs dark / hrs light): 14 / 10
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: Left eye served as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL - Duration of treatment / exposure:
- In three rabbits, the eyes were rinsed after 30 seconds. The test eye of the other three rabbits remained unwashed.
- Observation period (in vivo):
- 72 h
- Number of animals or in vitro replicates:
- 6 (3 male and 3 female)
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): After 30 seconds the compound was, as far as possible, flushed out of the eyes of three of the rabbits with approximately 200 ml of warm water.
SCORING SYSTEM: method described in "Appraisal of the Safety of Chemicals in Food, Drugs, and Cosmetics" page 51, published by the Association of Food and Drug Officials of the U.S.A. (see appendix 1)
TOOL USED TO ASSESS SCORE: Corneal damage was assessed after staining with fluorescein.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- unwashed eyes
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: minimal effects observed in one rinsed eye
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- unwashed eyes
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Remarks on result:
- other: no effects
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Remarks:
- unwashed eyes
- Time point:
- 24/48/72 h
- Score:
- 0.2
- Max. score:
- 3
- Reversibility:
- fully reversible within: 48 h
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- unwashed eyes
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- fully reversible within: 24 h
- Remarks on result:
- other: minimal chemosis observed after 1 h
- Irritant / corrosive response data:
- Minimal conjunctival redness was observed in both rinsed and unrinsed eyes at the 1h and 24 h timepoint. In addition, in on rinsed eye minimal corneal opacity was observed. All effects were reversible within 48 hours the latest.
Any other information on results incl. tables
EXPERIMENTAL RESULT
Animal Number | 11 | 13 | 15 (rinsed) | 12 | 14 (rinsed) | 16 (rinsed) | ||||||||||||||||||
Timepoint (hrs) | 1 | 24 | 48 | 72 | 1 | 24 | 48 | 72 | 1 | 24 | 48 | 72 | 1 | 24 | 48 | 72 | 1 | 24 | 48 | 72 | 1 | 24 | 48 | 72 |
Cornea | ||||||||||||||||||||||||
Opacity | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Area | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Iris | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Conjunctivae | ||||||||||||||||||||||||
Redness | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 2 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Chemosis | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Discharge | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mean values after 24, 48 and 72 hours for animals with non-rinsed eyes are:
Iris: 0
Corneal Opacity: 0
Conjunctival Redness: 0.2
Chemosis: 0
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test substance caused minimal conjunctival effects in all animals and minimal corneal opacity in one animal; all effects were reversible within 48 hours.
- Executive summary:
The occular irritation potential of the test substance was assessed in an in vivo study performed with six New Zealand White rabbits. The eyes of the experimental animals were examined and found normal prior to the test. 0.1 mL of the test compound were instilled into the conjunctival sac of the left eye. The eyelids were then held closed for 1 second. The right eye served as a control. After 30 seconds the compound was, as far as possible, flushed out of the eyes of three of the rabbits with approximately 200 ml of warm water. The rabbits were examined 1, 24, 48 and 72 hours after application of the test compound and for any further period that was considered necessary. The ocular reactions were scored by the method described in "Appraisal of the Safety of Chemicals in Food Drugs and Cosmetics" page 51, published by the Association of Food and Drug Officials of the USA. Corneal damage was assessed after staining with fluorescein. A very slight to slight conjunctival reaction was seen in all treated eyes one hour after application of the compound. This was still present in three eyes (2 unwashed, 1 washed) at 24 hours. Damage to the surface epithelium of the cornea with slight opacity was seen at 24 hours only in one washed eye. After 48 hours, all occular effects had reversed. Therefore, the substance was considered to be not irritating to eyes.
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