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EC number: 220-237-5 | CAS number: 2680-03-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
N,N-dimethylacrylamide was tested for its skin sensitising properties in the guinea pig maximization test based on the method of Magnusson and Kligman (Product Safety Laboratories, 2003), comparable to OECD guideline 406. Ten female animals were induced intradermally with 6 injections (2 injections each of 0.1 ml 50% v/v Freund's adjuvant; 2 injections each of 0.1 ml of the test substance formulation (5% w/w solution) and 2 injections each of 0.1 ml 5% v/v Freund's adjuvant with the test substance (5% w/w solution)) and one week later epicutaneously with 25% solution of the test substance for 48 hours. Twenty-one days after intradermal induction animals were challenged epicutaneously with 25% solution of the test substance for 24 hours. The skin reactions were scored 24 and 48 hours later. One naive control group was used, which was given the same injections (A, B C) but without test substance, only with the formulating agent. Alpha-hexylcinnamaldehyde was used as a positive control. After the challenge (24 hours after removal of the patch) with the 25% test substance preparation, very faint erythema (0.5) was noted at five of ten test sites 24 hours following the challenge application. Similar irritation persisted at two sites through 48 hours. In the control group, very faint erythema (0.5) was noted at one of five test sites 24 hours following the challenge application. All animals were free of irritation by 48 hours. In the test with the positive control alpha-hexylcinnamaldehyde, 6 out of 10 test animals showed faint to moderate erythema (1-2) 24 and 48 hours after challenge patch removal. Very faint erythema (0.5) was noted for three other sites at the 24 and 48 hour interval.
According to the evaluation criteria as outlined in the study report, erythema scores of 0.5 or less are not considered to be positive responses. Therefore, based on the results of the study N,N-dimethylacrylamide was considered to be not sensitising to the skin.
Migrated from Short description of key information:
N,N-dimethylacrylamide is not considered to be a skin sensitiser.
Justification for classification or non-classification
Based on the result of the skin sensitisation test, the substance does not need to be classified according to Directive 67/548/EEC and according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
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