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EC number: 425-180-1 | CAS number: 66170-10-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 5.2 mg/m³
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 15
- Modified dose descriptor starting point:
- NOAEC
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 75.25 mg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
DNEL related information
- Overall assessment factor (AF):
- 120
- Modified dose descriptor starting point:
- NOAEL
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
Short-term and local effects DNELS:
Acute/short-term DNELS were not determined as no acute toxic effects occured after oral and dermal administration to rats. Also no local dermal or iritating effects were observed on skin and eye irritation/corrosion and sensitisation. No inhalation irritation and sensitisation properties are expected from experience in handling and use of Sodium Ascorbyl Phosphate.
The following DNEL(s) for local and short term effects were not determined:
- Dermal DNEL for acute / short-term exposure - systemic effects
- Inhalation DNEL for acute / short-term exposure - systemic effects
- Dermal DNEL for acute / short-term exposure - local effects
- Inhalation DNEL for acute / short-term exposure - local effects
- Dermal DNEL for long-term exposure - local effects
- Inhalation DNEL for long-term exposure - local effects
Long-term systemic effects DNELS:
Derivation of DNELlong-term, dermal
The NOAELlong-term, dermalwas 90.3 mg/kg bw/day, calculated from the NOAELlong-term, oral, assuming 1 % resorption through the skin (see dermal absorption study). The NOAELlong-term, oral was 90.3 mg/kg bw/day derived in a 28 day toxicity study (EU-B.7) with rats. An assessment factor of 120 was applied to the NOAELlong-term, dermal consisting of a factor of 4 for the allometric scaling from rat to humans, a factor of 5 for the intraspecies differences (workers) and a factor of 6 for extrapolation from subacute to chronic exposure. No additional factor of 2.5 for other interspecies differences was used as Sodium Ascorbyl Phoshate is metabolized to Ascorbic Acid (physiological molecule). Thus no additional differences in toxicokinetics and metabolism are expected.
This results in a DNEL long-term, dermal of 75.25 mg/kg bw/day.
Derivation of DNELlong-term, inhalation
The DNELlong-term, inhalationwas derived from the NOAELlong-term, oralof 90.3 mg/kg bw/day. The NOAELlong-term, oralwas 90.3 mg/kg bw/day derived in a 28 day toxicity study (EU-B.7) with rats.
The corrected NOAELlong-term, inhalationwas derived according to the following formula assuming a 50 % absorption for rat, oral and a 100 % absorption for inhalation:
NOAELlong-term, inhalation= NOELlong-term, oral* 1/standard Resp. Vol.rat* Absorptionoral-rat/Absorptioninh-human* standard Resp. Vol.human/worker Resp. Vol.
= 90.3 mg/kg bw/day * 1/(0.38 m3/kg/d) * 50 %/ 100 % * 6.7m3/10 m3
= 79.6 mg/m3
For DNEL derivation, an assessment factor of 15 was applied to the NOAELlong-term, inhalationconsisting of a factor of 5 for the intraspecies differences (workers) and a factor of 3 (based on the evaluation of approx. 2200 repaeted dose studies on 661existing chemicals in the RepDose database, Escher et al.(2009) Evaluation of risk assessment factors for inter-species and time-extrapolation. Tox Letters 189S, S247, H34) for extrapolation from subacute to chronic exposure. No additional factor of 2.5 for other interspecies differences was used as Sodium Ascorbyl Phoshate is metabolized to Ascorbic Acid (physiological molecule). Thus no additional differences in toxicokinetics and metabolism are expected.
This results in a DNELlong-term, inhalationof 5.2 mg/m3.
General Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
No DNELS for the general population (Consumer) were determined. The use of Sodium Ascorbyl Phosphate in cosmetical products is covered by an other legislation and has thus not to be regarded under REACH.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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