Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 216-544-9 | CAS number: 1609-86-5
Additional toxicological data
Administrative data
- Endpoint:
- additional toxicological information
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: special investigation
Data source
Reference
- Reference Type:
- publication
- Title:
- Inhibition of carcinogen-induced neoplasia by sodium cyanate, tert-butylisocyanate, and benzyl isothiocyanate administered subsequent to carcinogen exposure
- Author:
- Wattenberg LW
- Year:
- 1 981
- Bibliographic source:
- Cancer Res 41, 2991-2994
Materials and methods
- Type of study / information:
- inhibition of carcinogen-induced neoplasia by tert-butylisocyanate
- Principles of method if other than guideline:
- The effects of sodium cyanate, tert-butyl isocyanate, and benzyl isothiocyanate on carcinogen-induced neoplasia were studied in experiments in which the test compound was fed starting·1 week following completion of carcinogen administrations.
- GLP compliance:
- no
Test material
- Reference substance name:
- tert-butyl isocyanate
- EC Number:
- 216-544-9
- EC Name:
- tert-butyl isocyanate
- Cas Number:
- 1609-86-5
- Molecular formula:
- C5H9NO
- IUPAC Name:
- 2-isocyanato-2-methylpropane
- Reference substance name:
- tert-butylisocyanate
- IUPAC Name:
- tert-butylisocyanate
- Details on test material:
- rwer-butylisocyanate was obtained from Aldrich
Constituent 1
Constituent 2
Results and discussion
Any other information on results incl. tables
Under these conditions, all three test compounds including tert-butylisocyanate exerted an inhibitory effect on the occurrence of 7,12-dimethylbenz(a)anthracene-induced neoplasia of the breast of Sprague-Dawley rats.
Applicant's summary and conclusion
- Executive summary:
The effects of sodium cyanate, tert-butyl isocyanate, and benzyl isothiocyanate on carcinogen-induced neoplasia were studied in experiments in which the test compound was fed starting·1 week following completion of carcinogen administrations.
Under these conditions, all three test compounds including tert-butylisocyanate exerted an inhibitory effect on the occurrence of 7,12-dimethylbenz(a)anthracene-induced neoplasia of the breast of Sprague-Dawley rats.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
