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EC number: 210-848-5 | CAS number: 624-48-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline with restrictions (method shortly described; LD50 expressed in mL/kg instead of mg/kg; animals not fasted before exposure).
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- method shortly described; LD50 expressed in mL/kg instead of mg/kg; animals not fasted before exposure.
- GLP compliance:
- no
- Remarks:
- GLP was not mandatory at the time of the study
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Dimethyl maleate
- EC Number:
- 210-848-5
- EC Name:
- Dimethyl maleate
- Cas Number:
- 624-48-6
- Molecular formula:
- C6H8O4
- IUPAC Name:
- dimethyl (Z)-but-2-enedioate
- Details on test material:
- - Name of test material (as cited in study report): dimethyl maleate
- Analytical purity: no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann, Germany.
- Weight at study initiation: 160-180 g.
- Housing: animal were housed in groups of 5 animals per cage.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- Observation period: 14 days.
- Doses:
- Doses: 1.0, 1.5, 1.8, 2.0, and 3.1 mL/kg (1150, 1750, 2070, 2300, 3565 mg/kg bw).
- No. of animals per sex per dose:
- 10
- Control animals:
- other: not necessary
- Statistics:
- The calculation of the LD50 was performed according to Fink and Hund, Arzneim.-Forsh 15, 1965, 624.
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 909 mg/kg bw
- 95% CL:
- 1 644 - 2 116
- Remarks on result:
- other: rat
- Mortality:
- Mortality occurred at doses of 1750 mg/kg bw and higher concentrations.
- Clinical signs:
- other: Toxic symptoms: reduction of general conditions.
Any other information on results incl. tables
LD 50= 1.66 mL/kg. The density of dimethyl maleate is 1.15 g/cm³ at 20 °C. Therefore LD50 expressed in mg/kg is calculated to be 1909 mg/kg.
Table 1. Acute oral toxicity results
Dosis mg/kg b.w |
Time of death |
Toxicological Results Dead animals/ Aanimals with symptoms/Animals used |
1150 |
- |
0/0/10 |
1750 |
2 -5d |
3/10/10 |
2070 |
2 -7d |
7/10/10 |
2300 |
2 -4d |
8/10/10 |
3565 |
4h -2d |
10/10/10 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Based on the study results and according to EU classification criteria, the test substance is classified as Acute Tox. 4, according to the CLP regulation.
- Executive summary:
Bayer (1977)
In an acute oral toxicity 10 non-fasted male rats were administered with 1150, 1750, 2070, 2300, 3565 mg/kg bw dimethyl maleate with a method similar to OECD guideline 401 with acceptable deviations (method shortly described; LD50 expressed in mL/kg instead of mg/kg; animals not fasted before exposure).
The animals were observed for 14 days after administration.
Mortality occurred at doses of 1750 mg/kg bw and higher concentrations. Reduction of general conditions was observed. The acute oral LD50 was calculated to be 1909 mg/kg bw.
Based on the study results and according to EU classification criteria, the test substance is classified as Acute Tox. 4, according to the EU-CLP regulation.
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