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Diss Factsheets
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EC number: 239-106-9 | CAS number: 15022-08-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2001-11-14 to 2002-02-08
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: non GLP-compliant screening study according to (not specified) OECD test guidelines principles and procedures of the GLP-regulations 1999/11/EC and Italian Decreto Legislativo 27 Gennaio 1992 n. 120
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- screening method
- Deviations:
- yes
- Principles of method if other than guideline:
- The number of animals was selected from availabe stock and allocated to treatment. Food was removed overnight prior to dosing. The next day (day 1) the required amount of test item was adminstered by gavage at a dose volume of 10 ml/kg using a rubber catheder attached to a syringe of suitable capacity. Food was made available approximately 4 hours after dosing. Animals were observed for clinical signs immediately upon dosing, approximately 1, 2 and 4 hours after dosing and daily thereafter.
Animals were weight on allocation to the study, prior dosing (day 1). They were subjected to gross necropsy examination for both external and internal abnormalities. - GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Diallyl carbonate
- EC Number:
- 239-106-9
- EC Name:
- Diallyl carbonate
- Cas Number:
- 15022-08-9
- Molecular formula:
- C7H10O3
- IUPAC Name:
- bis(prop-2-en-1-yl) carbonate
- Details on test material:
- - Name of test material (as cited in study report): DAC
- Physical state: colourless liquid
- Lot/batch No.: 011009
- Expiration date of the lot/batch: October 9, 2002
- Storage condition of test material: ambient conditions
- Other: RTC reference number 5979
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- Dose 1: 500 mg/kg bw (3 males)
Dose 2: 200 mg/kg bw (3 females)
Dose 3: 25 mg/kg bw (3 females) - No. of animals per sex per dose:
- Dose 1: 3 males
Dose 2: 3 females
Dose 3: 3 females - Control animals:
- no
Results and discussion
Any other information on results incl. tables
Dose (mg/kg) |
Sex |
Clinical signs |
Mortality |
Necropsy |
500 |
Male |
No clinical signs noted. All animals died on day 2. |
3/3 |
No abnormalities found. |
200 |
Female |
Hunched posture, piloerection, semi-closed eyes, reduced activity and green staining in the litter tray noted. One animal found dead on day 3. Recovery in surviving animals by day 7. |
1/3 |
Abnormal red fluid in the stomach of early decent animal and generalised yellow staining of the skin. Single, pale area (9x4 mm) on the left kidney noted in 1 of the 2 surviving animals. |
25 |
Female |
No clinical signs noted during the observation period. |
0/3 |
Abnormal clear/yellow oil in the stomach and in the jejunum, yellow/red mucoid material in all 3 animals. |
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The results obtained indicate the median lethal dose (LD50) to be in the region, or slightly in excess, of 200 mg/kg body weight.
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