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EC number: 203-581-0 | CAS number: 108-42-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The substance 3-chloroaniline shows acute toxicity effect by the oral,inhalation and dermal route in category 3.
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Principles of method if other than guideline:
- The acute toxicity study was conducted to evaluate the toxic effects of administration of 3-chloroaniline to rat by the oral route.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Control animals:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 256 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral lethal dose (LD50) of 3 -Chloroaniline in rat was found to be 256 mg/kg of body weight. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that 3 -Chloroaniline exhibits acute toxicity via the oral route in category 3.
- Executive summary:
The acute toxicity study was conducted to evaluate the toxic effects of administration of 3-chloroaniline to rat by the oral route. The rats were given the test substance by the oral route at a dose concentration of 256 mg/kg of 3-chloroaniline.The lethal dose (LD50) of 3 -Chloroaniline in rat was found to be 256 mg/kg of body weight. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that 3 -Chloroaniline exhibits acute toxicity via the oral route in category 3.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 256 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Principles of method if other than guideline:
- The acute toxicity study was conducted to evaluate the toxic effects of administration of 3-chloroaniline to mouse by the inhalative route.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Control animals:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- 550 other: mg/m3
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: LC50=550 mg/m3,when converted into mg/L it is equivalent to 0.55 mg/L.
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The lethal concentration (LC50) of 3 -Chloroaniline in mouse by the inhalative route was found to be 550 mg/m3. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that 3 -Chloroaniline exhibits acute toxicity via the inhalative route in category 3.
- Executive summary:
The acute toxicity study was conducted to evaluate the toxic effects of administration of 3-chloroaniline to mouse by the inhalative route.The mouse were given the test substance by the inhalative route at a dose concentration of 550 mg/m3 of 3-chloroaniline.The lethal concentration (LC50) of 3 -Chloroaniline in mouse was found to be 550 mg/m3. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that 3 -Chloroaniline exhibits acute toxicity via the inhalative route in category 3.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 550 mg/m³ air
- Quality of whole database:
- The data is K4 level.The data has been obtained from the experimental study from the journal of ‘Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure'.
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Principles of method if other than guideline:
- The acute toxicity study was conducted to evaluate the toxic effects of administration of 3-chloroaniline to cat by the dermal route.
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Species:
- cat
- Strain:
- not specified
- Sex:
- not specified
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Control animals:
- not specified
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 223 mg/kg bw
- Based on:
- test mat.
- Interpretation of results:
- Toxicity Category III
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal lethal dose (LD50) of 3 -Chloroaniline in cat was found to be 223 mg/kg of body weight. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that 3 -Chloroaniline exhibits acute toxicity via the dermal route in category 3.
- Executive summary:
The acute toxicity study was conducted to evaluate the toxic effects of administration of 3-chloroaniline to cat by the dermal route.The cat were given the test substance by the dermal route at a dose concentration of 223 mg/kg of 3-chloroaniline.The lethal dose (LD50) of 3 -Chloroaniline in cat was found to be 223 mg/kg of body weight. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that 3 -Chloroaniline exhibits acute toxicity via the dermal route in category 3.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 223 mg/kg bw
- Quality of whole database:
- The data is K4 level.The data has been obtained from the experimental study from the reliable journal ‘Gigiena Truda i Professional'nye Zabolevaniya'.
Additional information
Acute toxicity: oral
Based on various studies were reviewed for acute oral toxicity with Klimish rating 4 for the target as well as the read across substances for CAS: 108-42-9 considering the weight of evidence approach.
The results for target substance as well as analogues are summarized as follows
Sr. No |
Endpoint |
Effect values |
Species |
Sources |
1 |
LD50 |
256 mg/kg bw |
Rat |
Data from Publication for CAS :108-42-9 |
2 |
LD50 |
250 mg/kg bw |
Guinea pig |
Data from publication for CAS: 108-42-9 |
3 |
LD50 |
280 mg/kg bw |
Rat |
Data from publication for RA CAS: 108-45-2 |
Based on the studies summarized in the above table for target substance 3-chloroaniline and the read across substance m-phenylenediamine, the acute oral lethal dose (LD50) value was found to vary between 250 mg/kg bw to 280 mg/kg bw which qualifies for acute toxicity via the oral route as per CLP regulation. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that 3-chloroaniline exhibits acute toxicity via the oral route in the category 3.
Acute toxicity: inhalation
Based on various studies were reviewed for acute toxicity via the inhalation route for the target substances for CAS: 108-42-9 considering the weight of evidence approach.
The results for target substance are summarized as follows
Sr. No |
Endpoint |
Effect values |
Species |
Sources |
1 |
LC50 |
550 mg/m3 |
Mouse |
Data from Publication for CAS :108-42-9 |
2 |
LC50 |
500 – 800 mg/m3 |
Rat |
Data from publication for CAS: 108-42-9 |
Based on the studies summarized in the above table for target substance 3-chloroaniline, the lethal concentration (LC50) value was found to vary between 500-800 mg/m3 which qualifies for acute toxicity via the inhalation route as per CLP regulation. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that 3-chloroaniline exhibits acute toxicity via the inhalation route in the category 3.
Acute toxicity: dermal
Based on various studies were reviewed for acute dermal toxicity for the target substance for CAS: 108-42-9 considering the weight of evidence approach.
The results for target substance are summarized as follows
Sr. No |
Endpoint |
Effect values |
Species |
Sources |
1 |
LD50 |
223 mg/kg bw |
Cat |
Data from Publication for CAS :108-42-9 |
2 |
LD50 |
250 mg/kg bw |
Rat |
Data from publication for CAS: 108-42-9 |
Based on the studies summarized in the above table for target substance 3-chloroaniline,the acute dermal lethal dose (LD50) value was found to vary between 223 mg/kg bw to 250 mg/kg bw which qualifies for acute toxicity via the dermal route as per CLP regulation. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that 3-chloroaniline exhibits acute toxicity via the dermal route in the category 3.
Justification for selection of acute toxicity – oral endpoint
The acute toxicity study was conducted to evaluate the toxic effects of administration of 3-chloroaniline to rat by the oral route. The rats were given the test substance by the oral route at a dose concentration of 256 mg/kg of 3-chloroaniline.The lethal dose (LD50) of 3 -Chloroaniline in rat was found to be 256 mg/kg of body weight. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that 3 -Chloroaniline exhibits acute toxicity via the oral route in category 3.
Justification for selection of acute toxicity – inhalation endpoint
The acute toxicity study was conducted to evaluate the toxic effects of administration of 3-chloroaniline to mouse by the inhalative route.The mouse were given the test substance by the inhalative route at a dose concentration of 550 mg/m3 of 3-chloroaniline.The lethal concentration (LC50) of 3 -Chloroaniline in mouse was found to be 550 mg/m3. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that 3 -Chloroaniline exhibits acute toxicity via the inhalative route in category 3.
Justification for selection of acute toxicity – dermal endpoint
The acute toxicity study was conducted to evaluate the toxic effects of administration of 3-chloroaniline to cat by the dermal route.The cat were given the test substance by the dermal route at a dose concentration of 223 mg/kg of 3-chloroaniline.The lethal dose (LD50) of 3 -Chloroaniline in cat was found to be 223 mg/kg of body weight. Thus by considering the CLP criteria for acute toxicity rating for the chemicals, it infers that 3 -Chloroaniline exhibits acute toxicity via the dermal route in category 3.
Justification for classification or non-classification
Based upon the study results and available information,the substance 3-chloroaniline shows acute toxicity effect via the oral,inhalation and dermal route in category 3 as per CLP regulation.
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