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EC number: 429-290-0 | CAS number: 3380-30-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1998-11-25 to 1998-12-3
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: OECD guideline study, GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Version / remarks:
- (1992)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- (1992)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 429-290-0
- EC Name:
- -
- Cas Number:
- 3380-30-1
- Molecular formula:
- C12 H8 Cl2 O2
- IUPAC Name:
- 5-chloro-2-(4-chlorophenoxy)phenol
- Details on test material:
- - Name of test material (as cited in study report): FAT 80'220/A
- Physical state: solid, powder
- Analytical purity: >99 %
- Lot/batch No.: GRU 98
- Expiration date of the lot/batch: 2008-10-31
- Stability under test conditions: stability of test item in bidistilled water not specified.
- Storage condition of test material: in the original container at room temperature (approx. 20°C) away from direct sunlight; the test item was stable under storage conditions.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Elevage Scientifique des Dombes, Chatillon sur Chalaronne, France
- Age at study initiation: 15 weeks
- Weight at study initiation: 2806 g (female), 2832 g (female), 2987 g (male)
- Housing: Individually in stainless steel cages
- Diet: Pelleted standard Provimi Kliba 3410 rabbit maintenance diet ad libitum
- Water: Community tap water from Itingen, ad libitum, in water bowls
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/- 3°c
- Humidity (%): 40 - 70 %
- Air changes (per hr): 10 - 15 air changes/ hour
- Photoperiod (hrs dark / hrs light): 12 hours dark/ 12 hours light
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: the dorsal fur (10 × 10 cm²) was clipped with an electric clipper 3 days before treatment.
- Vehicle:
- water
- Controls:
- other: the untreated skin of each animal served for control.
- Amount / concentration applied:
- An amount of 0.5 g of the test item was moistened with bidistilled water and applied onto the skin.
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 72 hours
- Number of animals:
- 3 animals
- Details on study design:
- TEST SITE
The area of exposure was about 6 cm². The wrap used consisted of a semi-occlusive dressing anchored with tape.
REMOVAL OF TEST SUBSTANCE
After 4 hours of exposure, the test patch was removed and the skin was flushed with lukewarm tap water
READING
Reading ot the skin for reaction was done at 1, 24, 48, 72 h after removal of the test patch.
SCORING SYSTEM:According to Draize scoring system.
Erythema 0-4:
0: No erythema,
1: very slight erythema (barely perceptible),
2: well-defined erythema,
3 moderate to severe erythema,
4: severe erythema (beet redness) to slight eschar formation (injuries in depth).
Edema 0-4:
0: No edema,
1: very slight edema (barely perceptible),
2: well-defined edema (edges of area well-defined by definite raising),
3: moderate to severe edema (raised approximately 1 mm),
4: severe edema (raised more than 1 mm extending beyond the area of exposure).
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- animal 1
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: At none of the reading time points erythema was seen.
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- animal 2
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: At none of the reading time points erythema was seen.
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- animal 3
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: At none of the reading time points erythema was seen.
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- animal 1
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: At none of the reading time points edema was seen.
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- animal 2
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: At none of the reading time points edema was seen.
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- animal 3
- Time point:
- other: 24, 48, 72 hours
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: not applicable
- Remarks on result:
- other: At none of the reading time points edema was seen.
- Irritant / corrosive response data:
- There were no signs of irritation on any rabbit at any of the examination time points.
- Other effects:
- Neither mortality nor clinical signs of toxicity were evident.
The test item did not cause staining of the treated skin.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information According to current evaluation criteria, the test item is not an irritant, and does not need to be classified, either according to the EU Directive 67/548/EC or to the CLP Regulation 1272/2008.
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