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Diss Factsheets
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EC number: 220-290-4 | CAS number: 2702-72-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 17 Jun 1998 - 01 Jul 1998
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- GLP - Guideline study, tested with the source substance Dimethylammonium 2,4-dichlorophenoxyacetate (CAS No. 2008-39-1). In accordance to the ECHA guidance document “Practical guide 6: How to report read-across and categories (March 2010)”, the reliability was changed from RL1 to RL2 to reflect the fact that this study was conducted on a read-across substance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- , limited data on test atmosphere
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.2 (Acute Toxicity (Inhalation))
- Deviations:
- yes
- Remarks:
- , limited data on test atmosphere
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Dimethylammonium 2,4-dichlorophenoxyacetate
- EC Number:
- 217-915-8
- EC Name:
- Dimethylammonium 2,4-dichlorophenoxyacetate
- Cas Number:
- 2008-39-1
- IUPAC Name:
- N-methylmethanaminium (2,4-dichlorophenoxy)acetate
- Details on test material:
- - Name of test material (as cited in study report): Aminopielik 600 SL
- Physical state: brown liquid
- Analytical purity: 606 g/L
- Impurities (identity and concentrations):
chlorphenol. 0.16%
- Storage condition of test material: test substance was kept at temperature of 20 - 25 °C
- Other:
pH = 7 - 9
boiling point = about 100 °C
flash point = > 100 °C
d= 1.19 - 1.23 g/cm3
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 3 months
- Weight at study initiation: 190 - 245 g (males), 201 - 213 g (females)
- Housing: suspended stainless steel wire mesh, 5 animals per cage
- Diet: "Murigran" standard diet ad libitum
- Water: ad libitum
- Acclimation period: at least 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20.5 - 22.5
- Humidity (%): 50 - 65
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: chamber made of stainless-steel and glass
- Exposure chamber volume: 0.06 m³
- Source and rate of air: 17 L/min (17 air changes/h)
- System of generating particulates/aerosols: atomizer
TEST ATMOSPHERE
- Brief description of analytical method used:
The concentration of Aminopielik 600 SL was measured at least once an hour using a spectrophotometric method. The light absorbance was measured at wavelength 263 nm with a control sample as reference.
Taking air samples: 5 L of test air was being passed through a filter and flask containing 2 cm3 of ethanol.
- Rationale for the selection of the starting concentration:
Based on the data indicating low toxicity to animals after oral exposure (LD50 = 911 mg/kg for rats), the study was conducted with
Aminopielik 600 SL at concentrations close to the limit value (5 mg/L). - Analytical verification of test atmosphere concentrations:
- yes
- Duration of exposure:
- 4 h
- Concentrations:
- 5377 mg/m³ air ± 1352 (females)
5083 mg/m³ air ± 1422 (males) - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 15 days
- Frequency of observations and weighing:
The animals were observed during exposure, once after exposure on the test day 1 and then once daily after exposure. The nature of the toxicity as well as the onset, the intensity and the duration of the signs were recorded.
Mortality was checked twice daily, on weekend only once daily. Time of death and number of dead animals per dose were documented
Body weights were recorded at the beginning and at the end of the study, or after death of the animals
- Necropsy of survivors performed: yes
- Other examinations performed: external appearance of all internal organs, histopathology
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- >= 5 000 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Remarks on result:
- other: 2 male and 1 female animal died
- Mortality:
- 3 Male and 4 female animals survived the exposure to the test substance. The deaths of one male and one female animal was recorded on day 1 after exposure, another male animal died on day 2.
- Clinical signs:
- other: The animals in the test substance-exposed groups exhibited abnormalities during the exposures. Generally, they showed signs of laboured or irregular breathing and body convulsions. Upon removal from the chamber most of the animals continued to exhibit la
- Body weight:
- Mean body weight of males decreased slightly during the first week and increased during the second week of observation.
Mean body weight of females decreased slightly during the second week of observation. - Gross pathology:
- Examinations revealed no pathological changes.
- Other findings:
- - Other observations:
Mean water and food consumption of males increased during the second week.
Mean water and food consumption of females was similar during both weeks.
Any other information on results incl. tables
concentration (mg/m3) |
Mortality per group (animals) |
|
Females |
Males |
|
5083 |
1 |
|
5377 |
|
2 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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