Registration Dossier
Registration Dossier
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EC number: 220-357-8 | CAS number: 2736-18-7
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 05.03 - 13.03.1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4,6-dichloro-1,3,5-triazin-2(1H)-one, sodium salt
- EC Number:
- 220-357-8
- EC Name:
- 4,6-dichloro-1,3,5-triazin-2(1H)-one, sodium salt
- Cas Number:
- 2736-18-7
- Molecular formula:
- C3HCl2N3O.Na
- IUPAC Name:
- 4,6-dichloro-1,3,5-triazin-2(1H)-one, sodium salt
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Duration of treatment / exposure:
- 3 Minutes and 1 Hour and 4 hours
- Observation period:
- 72 hours
- Number of animals:
- 3
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 0
- Max. score:
- 1
- Reversibility:
- fully reversible
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- ca. 0
- Max. score:
- 0
- Reversibility:
- fully reversible
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Aquacros is classified as non-irritant
- Executive summary:
NHDT was applied at intact skin of 3 female rabbits for 3 Minutes, 1 hour and 4 hours.
at all applications no to very slight erythema were observed. This leads to a classification as non-irritant.
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