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Diss Factsheets
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EC number: 205-861-8 | CAS number: 156-62-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 10 µg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 22 µg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 1 µg/L
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
- PNEC marine water (intermittent releases):
- 2.2 µg/L
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 1.09 mg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- no hazard identified
Sediment (marine water)
- Hazard assessment conclusion:
- no hazard identified
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 0.151 mg/kg soil dw
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
For detailled description where read across is used/recommended and where it is preferrable to refain from read across, please see section 13.2 "read across justification for environmental endpoints" and "Scientific rationale for not using cyanamide as read-across substance for calcium cyanamide on toxicological endpoints"
Conclusion on classification
Acute toxicity
Invertebrates are the most sensitive species to the toxic effects of calcium cyanamide with an acute EC50 of 4.2 mg calcium cyanamide/L (corresponding to 2.2 mg cyanamide/L). Based on the results obtained in the aquatic toxicity studies, calcium cyanamide does not have to be classified regarding acute toxicity to the environment.
Chronic toxicity
The acute toxicity data set of calcium cyanamide is supplemented by chronic toxicity data of the relevant transformation product cyanamide in a read-across approach (for justification for read-across for the aquatic compartment please refer to the read-across report attached to IUCLID section 13). The most sensitive chronic toxicity value was reported for reproduction of D. magna. The 21-d NOEC value of 0.1044 mg cyanamide/L obtained in this study (Murrell & Leak, 1995) corresponds to 0.199 mg calcium cyanamide/L.
Calcium cyanamide cannot be considered as readily biodegradable based on the results obtained in a screening test (OECD 301B, CO2 evolution test). However, higher tier testing with the relevant transformation product cyanamide resulted in DT50 values for the water/sediment system of 2.5 days and 4.8 days in river and pond systems, respectively. For the water phase the corresponding DT50 values were 2.3 days in rivers and 4.3 days in ponds. Elimination of [14C]-hydrogen cyanamide from the water/sediment systems occurred mainly via mineralisation to CO2. Only one major metabolite, identified as urea, was detected in the pond system. For urea DT50 values of 2.9 days (river) and 7.6 days (pond) for the whole systems and half-lives of 2.7 days (river) and 7.5 days (pond) for the water phase were calculated. In the sediments, neither the parent substance nor any degradation products were detected in significant amounts.
As rapid degradation of cyanamide could clearly be demonstrated under environmentally relevant conditions in the two aerobic water/sediment model systems (see IUCLID section 5.2.2), the substance as well as the read-across partner calcium cyanamide can thus be considered as rapidly degradable according to the CLP Regulation (EC) No 1272/2008, Annex I sections 4.1.2.9.2 and 4.1.2.9.3.
Consequently, calcium cyanamide is classified for chronic aquatic toxicity category Chronic 3 according to Regulation (EC) No 1272/2008 (CLP).
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