Registration Dossier
Registration Dossier
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EC number: 208-307-3 | CAS number: 521-18-6
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
The hydrolytic stability of androstanolone was estimated on basis of its chemical structure and the hydrolytic behaviour of a structurally similar compound.
Analytical Development Physical Chemistry, Schering AG, Berlin. Study report A08710 (ADP 2002_112), dated 200-206-03.
Result: Androstanolone can be expected to be hydrolytically stable at in the pH region 7 to 9 (at 25°C).
Key value for chemical safety assessment
Additional information
The test substance does not contain any functional group, which is susceptible to hydrolytic degradation. Thus hydrolytic stability is to be expected.
This is experimentally supported by the results of a hydrolysis study with 4-androstene-3,17 -dione, which differs in an additional double bond in ring A and a ketone- instead of a hydroxy group in position17 and was found to be hydrolytically stable in the pH region 4 to 9.
The same behaviour is to be expected for androstanolone.
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