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EC number: 221-416-0 | CAS number: 3088-31-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
- Qualifier:
- according to guideline
- Guideline:
- other: Estimated data
- Principles of method if other than guideline:
- Prediction is done using QSAR Toolbox version 3.1
- GLP compliance:
- no
- Type of study:
- mouse local lymph node assay (LLNA)
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Route:
- other: no data
- Vehicle:
- no data
- Route:
- other: no data
- Vehicle:
- no data
- Positive control substance(s):
- not specified
- Vehicle:
- not specified
- Parameter:
- other: Migrated information from in vivo LLNA study
- Remarks on result:
- other: Reading: 1st reading. Group: test group. Dose level: details not available. Clinical observations: sensitizing to skin.
- Parameter:
- SI
- Remarks on result:
- other: EC3 percentage = 11.8 % (sensitizing)
- Parameter:
- other: disintegrations per minute (DPM)
- Remarks on result:
- other: EC3=positive
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In vivo LLNA study on mouse for skin sensitisation with sodium 2-(2-dodecyloxyethoxy) ethyl sulphate showed EC3 percentage of 11.8% this predicted value of percentage indicates that the test substance was found to be sensitizing to skin of mouse.
- Executive summary:
In vivo LLNA study on mouse for skin sensitisation with sodium 2-(2-dodecyloxyethoxy) ethyl sulphate showed EC3 percentage of 11.8% this predicted value of percentage indicates that the test substance was found to be sensitizing to skin of mouse.
Reference
The prediction was based on dataset comprised from the following descriptors: EC3
Estimation method: Takes average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain
((("a" or "b" or "c" or "d" or "e" or "f" ) and ("g" and ( not "h") ) ) and ("i" and "j" ) )
Domain logical expression index: "a"
Referential boundary: The target chemical should be classified as Alkoxy AND Ether AND Sulfate by Organic functional groups
Domain logical expression index: "b"
Referential boundary: The target chemical should be classified as Alkoxy AND Ether AND Sulfate by Organic functional groups (nested)
Domain logical expression index: "c"
Referential boundary: The target chemical should be classified as Aliphatic Carbon [CH] AND Aliphatic Carbon [-CH2-] AND Aliphatic Carbon [-CH3] AND Miscellaneous sulfide (=S) or oxide (=O) AND Oxygen, aliphatic attach [-O-] AND Suflur {v+4} or {v+6} AND Sulfate, linear [-O-SO2-O-] AND Sulfite, linear [-OS(=O)O-] by Organic functional groups (US EPA)
Domain logical expression index: "d"
Referential boundary: The target chemical should be classified as Anion AND Cation AND Dialkylether AND Ether AND Sulfuric acid derivative by Organic functional groups, Norbert Haider (checkmol)
Domain logical expression index: "e"
Referential boundary: The target chemical should be classified as Group 1 - Alkali Earth Li,Na,K,Rb,Cs,Fr AND Group 14 - Carbon C AND Group 16 - Oxygen O AND Group 16 - Sulfur S by Chemical elements
Domain logical expression index: "f"
Referential boundary: The target chemical should be classified as Alkali Earth by Groups of elements
Domain logical expression index: "g"
Referential boundary: The target chemical should be classified as Group 1 - Alkali Earth Li,Na,K,Rb,Cs,Fr AND Group 14 - Carbon C AND Group 16 - Oxygen O AND Group 16 - Sulfur S by Chemical elements
Domain logical expression index: "h"
Referential boundary: The target chemical should be classified as Group 15 - Nitrogen N OR Group 17 - Halogens Cl OR Group 17 - Halogens F,Cl,Br,I,At by Chemical elements
Domain logical expression index: "i"
Parametric boundary:The target chemical should have a value of log Kow which is >= -0.104
Domain logical expression index: "j"
Parametric boundary:The target chemical should have a value of log Kow which is <= 1.69
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
Skin sensatization:-
Based on studies of target substance CAS NO 3088-31-1 and read across reviewed for skin sensitization from reliable sources having Klimisch rating 2 and 4considering the weight of evidence approach.
The summary of the results are presented below
Sr. No
End point
effect
Species
Remark
1
Skin sensitization
sensitizing
Mouse
Predicted data of target chemical
2
Skin sensitization
sensitizing
guinea pig
Data is from publication for CAS NO 151-21-3
3
Skin sensitization
sensitizing
guinea pig
Data is from publication for CAS NO 151-21-3
4
Skin sensitization
sensitizing
Humans
Data is from publication for CAS NO 151-21-3
Based on results summarized in above table for the target chemical CAS NO 3088-31-1 and read across, it can be concluded that the substance is sensitizing to the skin of human and guinea pig.Thus Sodium 2-(2-dodecyloxyethoxy) ethyl sulphate is considered to be sensitizing to skin as per the criteria of CLP regulation and will be classified as skin sen. category 1.
Migrated from Short description of key information:
Test substance sodium 2-(2-dodecyloxyethoxy) ethyl sulphate was found to be sensitizing to mouse and human skin.
Justification for selection of skin sensitisation endpoint:
In vivo LLNA study on mouse for skin sensitisation with sodium 2-(2-dodecyloxyethoxy) ethyl sulphate showed EC3 percentage of 11.8% this predicted value of percentage indicates that the test substance was found to be sensitizing to skin of mouse.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
The test substance sodium 2-(2-dodecyloxyethoxy) ethyl sulphate is considered as sensitising for the purpose of classification.
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