Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 428-100-3 | CAS number: 94239-04-0
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Toxicity studies have shown clear evidence for the absorption of the test substance following both oral administration and inhalation exposure. There was no evidence of any dermal penetration of the test substance in the rabbit, despite occluded application. Similarly, there was no evidence of any dermal absorption in the guinea pig sensitization study. An assessment of the potential absorption of the test substance is also based upon its physico-chemical properties, which suggest that the intact molecule would be subject to absorption across the gastrointestinal mucosa following oral administration and also via the lungs during inhalation exposure. The aqueous solubility of the test substance would allow some direct urinary excretion of the absorbed dose, but biotransformation would be expected. The fluorine and trifluoromethyl moieties are unlikely to be subject to metabolism. Ring hydroxylation would be expected to be a predominate reaction and, by analogy to trifluoromethylpyridine, would form metabolites of less toxicity. N-oxidation is feasible, although sulphate conjugation of this product would be expected to protect against its potential toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
