Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 244-599-9 | CAS number: 21829-50-5
Endpoint summary
Administrative data
Description of key information
Additional information
No substance-specific data are available for tris[(2-hydroxyethyl)ammonium] citrate, however read-across from monoethanolamine and citric acid is used for the assessment to meet the majority of the standard REACH information requirements. Tris[(2 -hydroxyethyl)ammonium] citrate is the salt of monoethanolamine and citric acid. Monoethanolamine and citric acid are the starting materials for the synthesis of tris[(2-hydroxyethyl)ammonium] citrate, and the only difference is that in tris[(2-hydroxyethyl)ammonium] citrate the substances are present in its protonated form as a monoethanolammonium cation and as its deprotonated form as a citric acid anion. It is expected that the ecotoxicological properties of tris[(2-hydroxyethyl)ammonium] citrate shall be governed by the properties of monoethanolamine and citric acid (for more details see reporting format for the analogue approach in Appendix A.2).
No tests are available for hydrolysis, photodegradation in air and photolysis in water.
Tris[(2-hydroxyethyl)ammonium]rogen citrate is readily biodegradable under aerobic conditions. No simulation tests are available. The degradation rate constants used in the assessment are:
Degradation rate for hydrolysis |
6.93E-07 d-1 |
Degradation rate for photolysis |
6.93E-07 d-1 |
Degradation rate in air |
0 d-1 |
Degradation in STP |
24 d-1 |
Total biodegradation rate in water |
0.0462 d-1 |
Total biodegradation rate in sediment |
2.31E-03 d-1 |
Total biodegradation rate in soil |
0.0231 d-1 |
No BCF study is available for tris[(2 -hydroxyethyl)ammonium] citrate. Tris[(2 -hydroxyethyl)ammonium citrate is the neutral salt of monoethanolamine and citric acid. Monoethanolamine and citric acid are the starting materials for the synthesis of tris[(2-hydroxyethyl)ammonium] citrate, and the only difference is that in tris[(2-hydroxyethyl)ammonium] citrate the substances are present in their ionic forms as a monoethanolamine
cation and a citrate anion. It is expected that the ecotoxicological properties of tris[(2-hydroxyethyl)ammonium] citrate shall be governed by the properties of monoethanolamine and citric acid (for more details see reporting format for the analogue approach in Appendix A.2).In accordance with Column 2 of REACH Annex IX, the study does not need to be conducted as the substance can be expected to have a low potential for bioaccumulation (the log Kowof monoethanolamine is calculated to be -1.31, the log Kowof citric is calculated to be -1.55).
The Koc was calculated with KOCWIN™ v2.00 (U. S. EPA, 2008) using the Molecular Connectivity Index as tris[(2-hydroxylethyl)ammonium] citrate is an ionic substance. The calculated Koc value of 10 L/kg is used in the assessment.
No other data is available on the transport and distribution of tris[(2 -hydroxylethyl)ammonium] citrate in the environment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
