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Diss Factsheets
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EC number: 215-716-0 | CAS number: 1345-07-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Developmental toxicity / teratogenicity
Administrative data
- Endpoint:
- developmental toxicity
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Study published only as an abstract therefore it is not possible to fully assess reliability.
Data source
Reference
- Reference Type:
- publication
- Title:
- Effects of bismuth citrate on pregnant rats and rabbits.
- Author:
- Secker, RC
- Year:
- 1 993
- Bibliographic source:
- Teratology 1993 Aug;48(2):33A
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Study published as an abstract only - no information is provided regarding whether any guideline was followed, but the data suggest a similar design as described in OECD 414.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Bismuth citrate
- EC Number:
- 212-390-1
- EC Name:
- Bismuth citrate
- Cas Number:
- 813-93-4
- IUPAC Name:
- bismuth(3+) citrate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: dutch rabbits
- Details on test animals or test system and environmental conditions:
- - female Dutch rabbits
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: aqueous aluminium hydroxide
- Duration of treatment / exposure:
- Female rabbits: Days 8-20 of pregnancy inclusive (day of mating is Day 1 of pregnancy).
- Frequency of treatment:
- Once daily
- Duration of test:
- Approximately 23 days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
50, 100 or 200 mg/kg bw
Basis:
- Details on study design:
- On Day 30 the rabbits were subjected to autopsy and foetuses examined for external, visceral and skeletal abnormalities.
Examinations
- Fetal examinations:
- Rabbit foetuses were examined for external, visceral and skeletal abnormalities.
Results and discussion
Results: maternal animals
Maternal developmental toxicity
- Details on maternal toxic effects:
- Maternal toxic effects:yes
Details on maternal toxic effects:
Marked reduction in maternal body weight occurred in rabbits. No information regarding dose at which toxic effects occurred.
Results (fetuses)
- Details on embryotoxic / teratogenic effects:
- Embryotoxic / teratogenic effects:no effects
Details on embryotoxic / teratogenic effects:
It was concluded that no adverse effects upon pre- or post-implantation loss, numbers of viable foetuses or foetal development were apparent.
Effect levels (fetuses)
open allclose all
- Dose descriptor:
- NOEL
- Effect level:
- 200 mg/kg bw/day (nominal)
- Based on:
- no data
- Basis for effect level:
- other: teratogenicity
- Dose descriptor:
- NOEL
- Effect level:
- 200 mg/kg bw/day (nominal)
- Based on:
- no data
- Basis for effect level:
- other: embryotoxicity
- Dose descriptor:
- NOEL
- Effect level:
- 200 mg/kg bw/day (nominal)
- Based on:
- no data
- Basis for effect level:
- other: fetotoxicity
Fetal abnormalities
- Abnormalities:
- not specified
Overall developmental toxicity
- Developmental effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- It was concluded that no adverse effects of the test substance bismuth citrate upon pre- or post-implantation loss, numbers of viable foetuses or foetal development were apparent, even tested at systemic toxic doses.
- Executive summary:
In this study (Secker, 1993), which has been published as an abstract only, the test substance bismuth citrate was administered to female Dutch rabbits. On Day 30 (day of mating is Day 1 of pregnancy) the rabbits were subjected to autopsy and foetuses examined for external, visceral and skeletal abnormalities. Plasma bismuth levels were determined at the beginning and end of the treatment period. Plasma levels up to 420 ng/g were recorded. Maternal toxicity, manifest as a marked reduction in body weight, was apparent in the rabbit. Numbers of viable foetuses or foetal development was not affected.
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