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EC number: 206-055-9 | CAS number: 298-06-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Test guideline compliant study
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- Classification according to Draize system was not applicable due to severe dermal reaction.
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- Classification according to Draize system was not applicable due to severe dermal reaction
- GLP compliance:
- yes
Test material
- Reference substance name:
- Sodium O,O-diethyl dithiophosphate
- EC Number:
- 222-079-2
- EC Name:
- Sodium O,O-diethyl dithiophosphate
- Cas Number:
- 3338-24-7
- IUPAC Name:
- sodium O,O-diethyl dithiophosphate
- Reference substance name:
- Sodium, O,O-diethyl phosphorodithioate
- IUPAC Name:
- Sodium, O,O-diethyl phosphorodithioate
- Details on test material:
- - Name of test material (as cited in study report): Danafloat 123 (Sodium O,O-diethyl phosphorodithioate, EP1-Na)
- Molecular formula (if other than submission substance): (CH3CH2O)2PS2Na
- Physical state: light brown liquid
- Analytical purity: 49.2% w/w
- Impurities (identity and concentrations):
- Lot/batch No.: 80929-00
- Storage condition of test material: ambient in dark
- Other: pH 12.8
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: David Percival Ltd., Moston, Sandbach, Cheshire, UK
- Age at study initiation: 12 - 16 weeks
- Weight at study initiation: 3.03 - 3.16 kg
- Housing: suspended metal cages
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: minimum of 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17 - 21°C
- Humidity (%): 44 - 70%
- Air changes (per hr): 15/hour
- Photoperiod (hrs dark / hrs light): 12 hours light / 12 hours dark
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL
- Concentration (if solution): 49.2% active ingredient
VEHICLE
No vehicle used; test substance was applied as supplied. - Duration of treatment / exposure:
- 3 minutes, 1 hour and 4 hours
- Observation period:
- Approximately one hour following the removal of the patches and 24, 48 and 72 hours later as well as 7 and 14 days after exposure, the test sites were examined.
- Number of animals:
- 3; one animal was treated initially after which two additional animals were treated.
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 x 4 cm
- Type of wrap if used: elasticated corset
Results and discussion
In vivo
Results
- Irritation parameter:
- other: erythema and oedema
- Basis:
- animal: 1, 2 and 3
- Score:
- > 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: adverse reactions prevented the accurate evaluation of erythema and oedema.
- Other effects:
- No other effects.
Any other information on results incl. tables
Application of the test substance for 4 hours resulted in severe erythema and oedema, green coloured necrosis, haemorrhage of the dermal capillaries, loss of skin elasticity and flexibility, light brown discolouration of the epidermis, a hardened light brown-coloured scab, a hardened dark-brown / black-coloured scab, reduced regrowth of fur, glossy skin, scar tissue and well-defined erythema surrounding other skin reactions.
A one-hour application of the test material produced well-defied erythema, very slight oedema, haemorrhage of the dermal capillaries, loss of skin elasticity and flexibility, light brown discolouration of the epidermis, crust formation and reduced regrowth of fur.
A 3-minute application resultet in well-defined erythema, very slight oedema, loss of skin elasticity and slight desquamation.
On occasions it was not possible to accurately evaluate the erythema and oedema due to the other reactions observed.
No effects on bodyweight were observed during the 14-day observation period.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- The presence of scar tissue at one skin site following a 4-hour exposure period was indicative of full thickness tissue destruction. The test material Danafloat 123, containing 49.2% EP1-Na, is therefore classified as corrosive. Classification according to the Draize system was not applicable.
- Executive summary:
The study was performed to assess the irritatany potential of Danafloat 123, containing 49.2% EP1-Na, to the skin of rabbits. The method used followed the recommendations of the OECD guideline 404 and Method B4 of Comission Directive 92/69/EEC.
A 4 -hour semi-occluded application of the test material to intact skin produced severe erythema and oedema besides other severe skin reactions. As well, exposure durations of one hour and 3 minutes resulted in well-defined erythema and very slight to slight oedema, loss of skin elasticity, skin discolouration, crust formation and reduced regrowth of fur. On occasions, it was not possible to accurately evaluate the reythema and oedema due to the other skin reactions observed.
The presence of scar tissue at one skin site following a 4 -hour exposure period was indicative of full thickness tissue destruction. The test material was therefore classified as corrosive. Classification according to the Draize system was not applicable.
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