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Diss Factsheets
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EC number: 200-861-4 | CAS number: 75-33-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- no information on the test compound
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Propane-2-thiol
- EC Number:
- 200-861-4
- EC Name:
- Propane-2-thiol
- Cas Number:
- 75-33-2
- Molecular formula:
- C3H8S
- IUPAC Name:
- propane-2-thiol
- Test material form:
- liquid
- Details on test material:
- No details available
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River laboratories, Inc.
- Age at study initiation: no data
- Weight at study initiation: 200-350 g
- Housing: individually
- Diet (ad libitum): Purina lab chow #5001
- Water (ad libitum): tap water
- Acclimation period: at least 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 70 +/- 4
- Humidity (%): 40-60
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: glass and stainless steel chambers
- Exposure chamber volume: 38 liters
- Method of holding animals in test chamber: individually in stainless-steel wire-mesh cage
- Source and rate of air: 10 l/min
- System of generating vapors: water-jacketed counter-flow column maintained at ca. 80°F
- Treatment of exhaust air: no data
- Temperature, humidity in air chamber: 75 +/- 3°F, 50-70%
TEST ATMOSPHERE
- Brief description of analytical method used: Total hydrocarbon analysis
- Samples taken from breathing zone: no data - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- Total hydrocarbon analysis
- Duration of exposure:
- 4 h
- Concentrations:
- 22.55 mg/l (nominal)
10368.75 +/- 1202.66 ppm (32.24 mg/l, analytical) - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: during exposure and twice daily
- Body weight: prior exposure and on days 2,3, 4, 7 and 14
- Necropsy of survivors performed: yes
- Other examinations performed: no - Statistics:
- Not appropriate
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC0
- Effect level:
- > 32.24 mg/L air (analytical)
- Exp. duration:
- 4 h
- Remarks on result:
- other: > 10368 ppm, no mortality
- Mortality:
- No mortality was observed
- Clinical signs:
- other: Beginning 30 minutes after initiation of exposures, all animals exhibited hyperactivty and ataxia (for the first 3 hours of exposure), labored respiration, prostration (last 30 minutes of exposure), and squinted eyes. One male and two females had bloody c
- Body weight:
- The males exhibited reduced mean body weights through Day 4 post-exposure and the females exhibited reduced mean body weights through Day 7 post-exposure when compared to the respective pre-exposure mean body weights.
- Gross pathology:
- All animals appeared normal at the terminal sacrifice with the exception of one male observed with an enlarged left cervical lymph node.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Executive summary:
In a key study similar to OECD TG 403, Sprague-Dawley rats (5/sex) were exposed (whole-body) for four hours to propane-2-thiol at a measured concentration of 32.24 mg/l [10368 ppm]. Animals were observed for 14 days following the exposure. No mortality was observed. Beginning 30 minutes after initiation of exposures, all animals exhibited hyperactivty and ataxia, labored respiration, prostration, and squinted eyes. All animals appeared normal throughout the rest of the study with the exception of one female exhibiting urine stains through Day 3 postexposure. The males exhibited reduced mean body weights through Day 4 postexposure and the females exhibited reduced mean body weights through Day 7 postexposure. There was no evidence of macroscopic changes attributable to exposure. The 4-hour LC0 was > 32.24 mg/L (> 10368 pm).
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