Registration Dossier
Registration Dossier
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EC number: 204-557-2 | CAS number: 122-60-1
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented study which meets basic scientific principles.
Data source
Reference
- Reference Type:
- publication
- Title:
- DNA-cell-binding (DCB) assay for suspected carcinogens and mutagens
- Author:
- Kubinski H, Gutzke GE, Kubinski ZO
- Year:
- 1 981
- Bibliographic source:
- Mutation Research 89, 95-136
Materials and methods
- Principles of method if other than guideline:
- A DCB (DNA-cell-binding) assay was performed. The DCB investigated the formation of complexes of DNA with proteins and with other nucleic acid molecules in the presence of mutagens. The formation of adducts was detectable by the decreased yields of DNA recovered into water phase during cold phenol extraction of the cellular lysate of Ehrlich ascites cells.
- Type of method:
- in vitro
- Endpoint addressed:
- genetic toxicity
Test material
- Reference substance name:
- 1,2-epoxy-3-phenoxypropan
- IUPAC Name:
- 1,2-epoxy-3-phenoxypropan
- Details on test material:
- - Name of test material (as cited in study report): 1,2-epoxy-3-phenoxypropan
No further data provided.
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- ICR
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data.
Administration / exposure
Doses / concentrations
- Remarks:
- Doses / Concentrations:
10, 100 µmol (not further specified)
Basis:
Examinations
- Positive control:
- mehtylmethanfulfonate (MMS)
Results and discussion
- Details on results:
- If more than 1 % of DNA was found attached to intact animals cells (after subtracting the control values), such level of binding was considered indicative of a positive response. If the levels of binding in the chemical-containing tube were below those of the control sample, the figure "0.0" was given as result. For the test substance, less than 1% of DNA was found attached indicating a negative result.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
