Registration Dossier
Registration Dossier
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EC number: 207-325-9 | CAS number: 462-34-0
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
BASF (1995) reported an acute oral LD50 value of > 200 - < 2000 mg/kg. Male and female Wistar rats were administered (gavage) 200 and 2000 mg/kg (dissolved in olive oil). No animals died at 200 mg/kg; all animals died at 2000 mg/kg. Clinical signs found were impaired general state and dyspnea (200 mg/kg); poor general state, dyspnea, apathy, abdominal position, staggering, ataxia, paresis, cyanosis (2000 mg/kg). Pathological findings noted were hemorrhage in the mucosa of the stomach and substance discoloration of the contents in the small intestines (animals that died) indicating corrosion in the stomach; no abnormalities in survivors.
Data/studies concerning acute inhalation toxicity are not available.
Rusch et al. (1986) reported an acute inhalative LC50 value of 1210 mg/m3/4 h for boron trifluoride dihydrate (CAS: 13319-75-0). In this experiment, male and female Fischer-344 rats were offered concentrations of 1.01, 1.22, 1.32 and 1.54 mg/l (whole-body exposure). Deaths occurred in all exposure groups (9/10 t 1.54 mg/l; 8/10 at 1.32 mg/l; 2/10 at 1.22 mg/lg; 3/10 at 1.01 mg/l). Clinical signs elicited by the exposures included dry and moist rales, gasping, excessive oral and nasal discharge, lacrimation, indicative of respiratory distress and irritation. Recovery was apparent for the rats surviving beyond 6 days post-exposure.
Data/studies regarding acute dermal toxicity are not available.
Justification for classification or non-classification
Due to the corrosivity of diethyl ether boron trifluoride, testing regarding acute toxicity is not meaningful.
The structure-related test compound boron trifluoride is classified with T+ and R26 (EC) and Acute Tox. Cat. 2, H 330 (GHS). For test compound boron trifluoride dihydrate proposal for classification is Acute Tox. Cat. 4, H332 (GHS) and Xn, R20 (EC).
Classification proposal: Xn; R20 (EU); Acute Tox. 4 - H332 (GHS)Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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