Phenol, styrenated

Short-term toxicity to fish

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Justification for type of information:

Data is from authoritative database

Qualifier:

according to guideline

Guideline:

other: Refer below principle

Principles of method if other than guideline:

Study was designed to assess the effect of test chemical on the mortality of fish.

GLP compliance:

not specified

Analytical monitoring:

no

Vehicle:

no

Test organisms (species):

other: Fish

Test type:

not specified

Water media type:

not specified

Total exposure duration:

96 h

Hardness:

Not available

Test temperature:

Not available

pH:

Not available

Dissolved oxygen:

Not available

Salinity:

Not available

Nominal and measured concentrations:

Not available

Details on test conditions:

Not available

Reference substance (positive control):

not specified

Key result

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

5.6 mg/L

Nominal / measured:

meas. (not specified)

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other: Other details not known

Validity criteria fulfilled:

not specified

Conclusions:

The lethal concentration (LC50) value of test chemical in fish in a 96 hr study on the basis of mortality effect was determine to be 5.6 mg/L.

Executive summary:

Study was designed to assess the effect of test chemical on the mortality of fish. Test conducted for 96 hrs. The lethal concentration (LC50) value of test chemical in fish in a 96 hr study on the basis of mortality effect was determine to be 5.6 mg/L. The test chemical is highly insloluble in water the obtained LC50 value is much higher than the solubility of test chemical. Thus, by considering the solubility, test chemical cannot be toxic at its solubility limit.

Description of key information

Study was designed to assess the effect of test chemical on the mortality of fish. Test conducted for 96 hrs. The lethal concentration (LC50) value of test chemical in fish in a 96 hr study on the basis of mortality effect was determine to be 5.6 mg/L. The test chemical is highly insloluble in water the obtained LC50 value is much higher than the solubility of test chemical. Thus, by considering the solubility, test chemical cannot be toxic at its solubility limit.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish

Effect concentration:

5.6 mg/L

Additional information

Data available for the test chemical from various sources, study has been reviewed to determine the short term toxicity on fish of the test chemical. The studies are as mentioned below:

 

Study was designed to assess the effect of test chemical on the mortality of fish. Test conducted for 96 hrs. The lethal concentration (LC50) value of test chemical in fish in a 96 hr study on the basis of mortality effect was determine to be 5.6 mg/L. The test chemical is highly insloluble in water the obtained LC50 value is much higher than the solubility of test chemical. Thus, by considering the solubility, test chemical cannot be toxic at its solubility limit.

 

Similar short term toxicity of test chemical were studied on the mortality of fish. The lethal concentration LC0, LC50 and LC 100 value of test chemical in fish (Brachydanio rerio) in a 96 hr study on mortality effect was determine to be 1,3.2 and 10 mg/L. The test chemical is highly insloluble in water the obtained LC50 value is much higher than the solubility of test chemical. Thus, by considering the solubility, test chemical cannot be toxic at its solubility limit.

Thus based on the above data available from various sources, chemical consider to be non toxic at its maximum solubility limit.