Registration Dossier
Registration Dossier
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EC number: 206-026-0 | CAS number: 289-95-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non GLP study according to guidelines similar or equivalent to OECD guidelines.
Data source
Reference
- Reference Type:
- publication
- Title:
- Studies on the eye irritation caused by chemicals in rabbits.
- Author:
- Sugai, S., Murata, K., Kitagaki, T., Tomita, I.
- Year:
- 1 990
- Bibliographic source:
- The Journal of Toxicological Sciences 15, 245 - 262
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- Pyrimidine
- EC Number:
- 206-026-0
- EC Name:
- Pyrimidine
- Cas Number:
- 289-95-2
- Molecular formula:
- C4H4N2
- IUPAC Name:
- pyrimidine
- Test material form:
- gas under pressure: refrigerated liquefied gas
- Details on test material:
- - Name of test material: Pyrimidine
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: Japanese white rabbits
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated eye of the same animal
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- 21 days
- Number of animals or in vitro replicates:
- 3 female
Results and discussion
In vivo
Results
- Irritation parameter:
- other: non-standard
- Basis:
- mean
- Time point:
- other: 21 days
- Reversibility:
- not reversible
- Other effects:
- Corneal involvement; eye damage persisted for more than 21 days after treatment.
Any other information on results incl. tables
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information
- Conclusions:
- Based on the results obtained in this study the test item is considered corrosive.
- Executive summary:
A study was carried out equivalent or similar to EU Method B.5 and OECD Guideline 405 (Acute Eye Irritation / Corrosion). The test substance was corrosive to the eye according to the Draize scoring method: Corneal involvement, irritation or eye damage that persists for more than 21 days after treatment. Based on the results obtained the test item is considered corrosive.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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