Registration Dossier
Registration Dossier
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EC number: 206-026-0 | CAS number: 289-95-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according to OECD guidelines.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Report date:
- 1995
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Pyrimidine
- EC Number:
- 206-026-0
- EC Name:
- Pyrimidine
- Cas Number:
- 289-95-2
- Molecular formula:
- C4H4N2
- IUPAC Name:
- pyrimidine
- Test material form:
- gas under pressure: refrigerated liquefied gas
- Details on test material:
- - Name of test material: Pyrimidine
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 2000 mg/kg bw.
- No. of animals per sex per dose:
- 5 animals per sex per dose
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- 2 000 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the conditions of this study, the acute oral median lethal dosage (LD50) of the test material was greater than 2000 mg/kg bw.
- Executive summary:
A study was carried out according to EU Method B.1 and OECD Guideline 401 (Acute Oral Toxicity). Groups of 5 male and 5 female rats were administered 2000 mg/kg bw test item (limit dose) per oral gavage. Under the conditions of this study, the acute oral median lethal dosage (LD50) of the test material was greater than 2000 mg/kg bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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