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Diss Factsheets
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EC number: 202-090-9 | CAS number: 91-68-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- chronic toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Lack of Toxicity and Carcinogenicity of Some Commonly Used Cutaneous Agents
- Author:
- FREJ STENBACK AND PHILIPPE SHUBIK
- Year:
- 1 974
- Bibliographic source:
- TOXICOLOGY AND APPLIED PHARMACCLOGY 30, 7-13
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- The potential carcinogenicity and toxicity of several commonly used cutaneous agents of which one is resocersinol were studied in female Swiss mice by administering repeated applications of the chemical on the skin for the life-span of the animals
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Resorcinol
- Cas Number:
- Resorcinol
- Molecular formula:
- C6H6O2
- IUPAC Name:
- Resorcinol
- Reference substance name:
- 1,3-Benzenediol
- Cas Number:
- 108-46-3
- Molecular formula:
- C6H6O2
- IUPAC Name:
- 1,3-Benzenediol
- Reference substance name:
- Resorcinol
- EC Number:
- 203-585-2
- EC Name:
- Resorcinol
- Cas Number:
- 108-46-3
- Molecular formula:
- C6H6O2
- IUPAC Name:
- 1,3 benzenediol
- Details on test material:
- - Name of test material (as cited in study report):resorcinol
- Substance type: Organic
- Physical state: Solid
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Eppley colony
- Age at study initiation: Seven-week-old
- Weight at study initiation: no data
- Fasting period before study: no data
- Housing: plastic cages with commercial bedding
- Diet (e.g. ad libitum):commercial diet Wayne, Allied Mills, ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): no data
- Humidity (%): no data
- Air changes (per hr): no data
- Photoperiod (hrs dark / hrs light): no data
IN-LIFE DATES: From: To:
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- acetone
- Details on exposure:
- TEST SITE
- Area of exposure: dorsal skin between the flanks
- % coverage: l-inch square area
- Type of wrap if used: no data
- Time intervals for shavings or clipplings: shaved regularly.
REMOVAL OF TEST SUBSTANCE
- Washing (if done):no data
- Time after start of exposure:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.02 ml
- Concentration (if solution): 5, 25,50 %
- Constant volume or concentration used: no data
- For solids, paste formed: no data - Duration of treatment / exposure:
- life time
- Frequency of treatment:
- twice a week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0,5,25,50% (8333.33, 41666.6, 83333.3 mg/kg bw/day)
Basis:
nominal per unit area
- No. of animals per sex per dose:
- 50/dose group
- Control animals:
- yes, concurrent vehicle
- Positive control:
- 7,12-dimethylbenzanthracene
Examinations
- Sacrifice and pathology:
- The animals were checked weekly, and all lesions, as well as tumors, were recorded. Animals were allowed to die spontaneously or were killed when moribund. Complete autopsies were performed on all animals. The skin from all animals, all grossly observed tumors and other lesions in the lungs, livers, kidneys, etc., from treated as well as control groups were studied histologically. Formalin-fixed paraffin-embedded specimens were cut and stained with hematoxylin-eosin and other stains when needed.
- Statistics:
- The statistical significance of the results was evaluated using the methods presented by Armitage
Results and discussion
Results of examinations
- Clinical signs:
- no effects observed
- Dermal irritation:
- effects observed, treatment-related
- Mortality:
- no mortality observed
- Body weight and weight changes:
- not examined
- Food consumption and compound intake (if feeding study):
- not examined
- Food efficiency:
- not examined
- Water consumption and compound intake (if drinking water study):
- not examined
- Ophthalmological findings:
- not examined
- Haematological findings:
- not examined
- Clinical biochemistry findings:
- not examined
- Urinalysis findings:
- not examined
- Behaviour (functional findings):
- not examined
- Gross pathological findings:
- not examined
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Histopathological findings: neoplastic:
- effects observed, treatment-related
- Details on results:
- Animals treated with resorcinol showed skin lesions with ulceration, inflammation and hyperplasia. Two skin tumors were seen, 1 on the back and 1 on the ear as well as 1 subcutaneous fibrosarcoma.
Effect levels
- Dose descriptor:
- LOAEL
- Effect level:
- 8 333.33 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other: skin lesions with ulceration, inflammation and hyperplasia was observed
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The LOAEL of resorcinol in female swiss mice in a life time study was observed at dose concentration of 8333.33 mg/kg bw/day
- Executive summary:
50 female swiss mice were applied resorcinol at dose concentration of 0,5,25,50% (8333.33, 41666.6, 83333.3 mg/kg bw/day) (0.02 ml) were dropped on the dorsal skin between the flanks twice a week on a l-inch square area which was shaved regularly. The animals
were checked weekly, and all lesions, as well as tumors, were recorded. Animals treated with resorcinol showed skin lesions with ulceration, inflammation and hyperplasia. Two skin tumors were seen, 1 on the back and 1 on the ear as well as 1 subcutaneous fibrosarcoma. Hence the LOAEL was considered to be 8333.33 mg/kg bw/day.
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