Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 253-506-0 | CAS number: 37439-34-2
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1986
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1985
Materials and methods
- Principles of method if other than guideline:
- The test material was fed in the diet to male and female rats at targeted dose levels. Parameters evaluated were general health, food consumption, body weights and gains, haematology, serum chemistry, pre-study, mid-study and final urinanalysis, absolute and relative organ weights, gross lesions and histopathologic alterations.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- sodium 3,5,6-trichloro-2-pyridinol
- IUPAC Name:
- sodium 3,5,6-trichloro-2-pyridinol
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: feed
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 3-months
- Frequency of treatment:
- No data
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
0 (control) mg/kgBW/day
Basis:
other: targeted dose
- Remarks:
- Doses / Concentrations:
10 mg/kgBW/day
Basis:
other: targeted dose
- Remarks:
- Doses / Concentrations:
30 mg/kgBW/day
Basis:
other: targeted dose
- Remarks:
- Doses / Concentrations:
100 mg/kgBW/day
Basis:
other: targeted dose
- No. of animals per sex per dose:
- No data
- Control animals:
- yes
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- ca. 30 mg/kg bw/day (nominal)
- Based on:
- not specified
- Sex:
- male/female
- Basis for effect level:
- other: see 'Remark'
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Increased liver and kidney weights were observed in both males and females at the highest dose level.
During study, administration of the test material was also associated with observations of staining and matting of the perineal hair, often in females of the highest dose level, less often in females of the middle dose, occasionally on males of the highest dose group; and frequently in females of the low dose level group. The cause of this perineal soiling and its toxicological significance is uncertain.
Body weights and weight gains of the male middle dose level group increased along with increased food consumption, perhaps because of increased palatability.
No adverse gross or histopathological findings, urinalysis, serum chemistry, or haematology changes were found that corresponded with the increased relative liver and kidney weights, the perineal staining and matting, or the increased food consumption, body weights and body weight gains.
Applicant's summary and conclusion
- Conclusions:
- The NOAEL for males and females was 30 mg/kgBW/day.
- Executive summary:
Increased liver and kidney weights were observed in both males and females at the highest dose level.
During study, administration of the test material was also associated with observations of staining and matting of the perineal hair, often in females of the highest dose level, less often in females of the middle dose, occasionally on males of the highest dose group; and frequently in females of the low dose level group. The cause of this perineal soiling and its toxicological significance is uncertain.
Body weights and weight gains of the male middle dose level group increased along with increased food consumption, perhaps because of increased palatability.
No adverse gross or histopathological findings, urinalysis, serum chemistry, or haematology changes were found that corresponded with the increased relative liver and kidney weights, the perineal staining and matting, or the increased food consumption, body weights and body weight gains.
The NOAEL for males and females was 30 mg/kgBW/day.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
