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EC number: 700-493-9 | CAS number: 1228180-58-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12-Oct-2010 to 04-Mar-2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results. The study report was conclusive, done to a valid guideline and the study was conducted under GLP conditions.
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- Acid Yellow RN 2903
- IUPAC Name:
- Acid Yellow RN 2903
- Details on test material:
Identification: Acid Yellow RN 2903
Batch Number: Vers. Kilo 6, 26.05.2009
Purity: 65.7 %
Expiry Date: August 01, 2015
Storage Conditions: At room temperature at about 20 °C
Constituent 1
Study design
- Analytical method:
- high-performance liquid chromatography
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- < -3.4
- Temp.:
- 22 °C
- pH:
- 7.9
Any other information on results incl. tables
Neither the HPLC-method according to OECD Guideline No. 117 nor the flask-shaking method according to OECD Guideline No. 107 were applicable for the determination of the partition coefficient of Acid Yellow RN 2903. Thus, the log POW-value for the test item was estimated from its solubility in n-octanol and in water, respectively.
In the present study, the n-octanol solubility of Acid Yellow RN 2903 was determined to be < 2.501 µg/mL, which is below the concentration of the smallest calibration point (multiplied with the dilution factor). The water solubility was determined in the main test of Harlan Laboratories study D04382 and was found to be 6392.1 mg/L using the flask shaking method.
The tabulated values represent rounded results, which were obtained by calculation using the exact raw data.
A typical chromatogram of the smallest calibration point is given in the attached Figure 1. A typical chromatogram of a sample solution in n-octanol is given in the attached Figure 2. A typical HPLC chromatogram of a blank solution is shown in the attached Figure 3. An example of a calibration curve and the data for test item-standards is given in the attached Figure 4 and Table 2. The correlation coefficient r2was 0.9916 (optimum 1.0000). This reflects the linearity of the HPLC-system within the calibration range of 0.5002 µg/mL to 30.012 µg/mL of the test item.
The partition coefficient, log POW, of Acid Yellow RN 2903 was calculated from the individual solubilities in n-octanol and in water, respectively, to be:
log POW= log10 (<2.501 mg/L / 6392.1 mg/L) = <-3.4
Table1 Results obtained for the Solubility of Acid Yellow RN 2903 in n-Octanol
Initial Weight of Test Item |
n-Octanol |
Measured Concentration |
Dilution Factor |
Solubility in |
Mean |
[g] |
[mL] |
[mg/L] |
|
[mg/L] |
[mg/L] |
0.10 |
10 |
< 0.5002 |
5 |
< 2.501 |
< 2.501 |
0.11 |
10 |
< 0.5002 |
5 |
< 2.501 |
Applicant's summary and conclusion
- Conclusions:
- The partition coefficient, log POW, of Acid Yellow RN 2903 was calculated from the individual solubilities in n-octanol and in water, respectively, to be log POW = <-3.4 at about 22 °C. The pH in the aqueous phase was 7.9.
- Executive summary:
The determination of the partition coefficient log POWof Acid Yellow RN 2903 was performed using the flask shaking method as described in OECD guideline no. 117, “Preliminary estimate of the partition coefficient”.
Based on the results of the preliminary test, the partition coefficient, log POW, of Acid Yellow RN 2903 wasfoundto be below -2. Based on the individual solubilities in n‑octanol and in water, respectively, the log POWwas calculated to be:
log POW < -3.4 at about 22 °C
The pH in the aqueous phase was 7.9.
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