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EC number: 231-193-1 | CAS number: 7446-07-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1996-07-09 to 1996-07-26
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- Tellurium dioxide
- EC Number:
- 231-193-1
- EC Name:
- Tellurium dioxide
- Cas Number:
- 7446-07-3
- Molecular formula:
- O2Te
- IUPAC Name:
- tellurium dioxide
- Test material form:
- solid: particulate/powder
- Details on test material:
- - Name of test material (as cited in study report): Tellurium dioxide
- Substance type: inorganic
- Physical state: fine white powder
- Analytical purity: 99.99 %
- Lot/batch No.: 44/2
- Storage condition of test material: at ca. 20 °C
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Wiga, Sulzfeld, Germany
- Age at study initiation: 5-6 weeks old upon arrival
- Weight at study initiation:
- Fasting period before study: overneight
- Housing: five animals per cage (stainless steel cages, fitted with wire screen floor and front)
- Diet (e.g. ad libitum): standard laboratory rodent diet ad libitum
- Water (e.g. ad libitum): Tap water ad libitum.
- Acclimation period: 26 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3°C
- Humidity (%): between 60-91 %
- Air changes (per hr): ca 10 air changes/hour
- Photoperiod (hrs dark / hrs light): 12 hours Iight/12 hours dark cycle
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- maize oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 500 mg/mL
MAXIMUM DOSE VOLUME APPLIED: 10 mL/ kg max. Dose volume - Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 5 animals/ sex/ dose
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations were made within 1 hour and within 4 hours after dosing, and subsequently at least once daily throughout the observation period of 14 days; body weights were recorded on day 0, 3, 7 and 14.
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality occured during the 14-day observation period.
- Clinical signs:
- other: At 4 hours after dosing, all males showed signs of diarrhoea. No other clinical symptoms were observed.
- Gross pathology:
- Examination of the animals at autopsy did not reveal any treatment-related gross alterations.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LD50 for tellurium dioxide (powder) was determined to be above 5000mg/kg bw .
- Executive summary:
In an acute oral toxicity study according to OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method), wistar rats were given a single oral dose of tellurium dioxide (powder) in maize oil at a dose of 5000, mg/kg bw (5 animals/sex/ group) and observed for 14 days.
No mortality occurred. At 4 hours after dosing, all males showed signs of diarrhoea. No other clinical symptoms were observed.
Apart from a slight dip in body weight of one male on day 7, all animals gained weight during the 14-day observation period.
Examination of the animals at autopsy did not reveal any treatment-related gross alterations.
Since no mortality occurred during the 14-day observation period, the oral LD50of tellurium dioxide is considered to exceed 5000 mg/kg bw in both male and female rats.
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