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EC number: 222-437-8 | CAS number: 3470-98-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017-07-13 - 2017-10-11
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Version / remarks:
- OECD 1995
- Deviations:
- yes
- Remarks:
- see 'Principles of method if other than guideline'
- Principles of method if other than guideline:
- Protocol Deivations
1. The protocol states that, “Approximately 0.1 g of test substance (solid substances must be pulverized) will be added to three 10-mL glass stoppered test vessels.” The experiment was conducted using one glass vessel with a Teflon®-lined cap. The protocol misstated the standard process, which uses a glass vessel with the appropriate closure and requires a minimum of one test sample, not three. There is no impact to the quality of the results or interpretation of this study.
2. The protocol states that the test substance will be added to glass stoppered test vessels. The experiment was performed using glass vessels with Teflon®-lined caps. The Teflon®-lined closures are suitably inert and present no interference to the experiment.
3. The protocol states that the vessels will be removed and re-equilibrated for 24 hours at the test temperature (20 ± 0.5 °C) with occasional shaking. On test day three, the 72- and 48-hour vessels were removed, unwrapped, and observed to be in solution. The observation was performed at room temperature at approximately 20 °C. The samples were not equilibrated at 20 ± 0.5 °C. There is no estimated impact on the study and the Study Sponsor was notified at this time.
4. The protocol states that about five times the quantity of test substance (solid substances must be pulverized) needed to achieve the expected water solubility (determined as described above) will be weighed, the amount recorded, and added into each of three glass vessels. During the water solubility definitive experiment, the 72-hour sample was observed to be completely in solution during the 24 hour and 48 hour observations. The Study Director requested an additional 5 g of test substance be added to the 72-hour vessel to determine if it would go into solution. It was observed that the addition 5 g went into solution. The concentration of solute (substance) to solvent (water) was 1.998 g/mL following the 5 g addition. The Study Director terminated the study at this time, stating that the liquids are miscible in each other. This act caused the termination of the study. - GLP compliance:
- yes
- Type of method:
- flask method
- Key result
- Remarks on result:
- completely miscible
- Details on results:
- The maximum concentration of the substance tested in the definitive experiment was 19.9607 g substance dissolved into 10 mL of purified reagent water. The ratio of solute to solvent is 1.998 g/1.0 mL or effectively 2/1. The inverse of this ratio states that purified reagent water was soluble in substance at greater than or equal to 500 g of purified reagent water/1000 g of the substance. The substance remained in solution during all observations at ambient temperature following termination.
- Conclusions:
- The substance was determined to be 100% miscible with water by visual observation.
- Executive summary:
The water solubility of the test substance was determined according to OECD Guideline 105 and in accordance with GLP with the flask method. The substance was determined to be 100 % miscible with water by visual observation.
Reference
The protocol states that about five times the quantity of test substance (solid substances must be pulverized) needed to achieve the expected water solubility (determined as described above) will be weighed, the amount recorded, and added into each of three glass vessels. During the water solubility definitive experiment, the 72-hour sample was observed to be completely in solution during the 24 hour and 48 hour observations. The Study Director requested an additional 5 g of test substance be added to the 72-hour vessel to determine if it would go into solution. It was observed that the addition 5 g went into solution. The concentration of solute (substance) to solvent (water) was 1.998 g/mL following the 5 g addition. The Study Director terminated the study at this time, stating that the liquids are miscible in each other. This act caused the termination of the study.
Description of key information
The water solubility of the test substance was determined according to OECD Guideline 105 and in accordance with GLP with the flask method. The substance was determined to be 100 % miscible with water by visual observation.
Assumption (quantification required for CHESAR calculation): 1000 g/L
Key value for chemical safety assessment
- Water solubility:
- 1 000 g/L
- at the temperature of:
- 20 °C
Additional information
Key: McLean-2017a
The water solubility of the test substance was determined according to OECD Guideline 105 and in accordance with GLP with the flask method. The substance was determined to be 100 % miscible with water by visual observation.
supporting information: Taminco-2017
Water solubility of N-Butylpyrrolidone was investigated experimentally. For this purpose, water and N-Butylpyrrolidone were mixed in various ratios, miscibility was cheched visually. Revealed result: Test compound is fully miscilbe in water, from 0 to 100 %.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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