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EC number: 265-512-0 | CAS number: 65140-91-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Meets generally accepted scientific standards, well documented and acceptable for assessment. No Purity of test substance available. No scores for the 48 h time point recorded, however, since all scores at 24 and 72 hours were 0, this deficiency is considered not to affect the interpretation of the study results.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: AFDO (1959) Appraisal of the safety of chemicals in Foods, Drugs and cosmetics.
- Principles of method if other than guideline:
- Draize test: Three male and three female rabbits were treated with a gauze patch, soaked with the test substance (0.5 g). The animals were treated with intact and scarificed skin for 24 h under occlusive conditions. The skin reactions were evaluated 24 h and 72 h after removal of test substance.
- GLP compliance:
- no
Test material
- Reference substance name:
- Calcium diethyl bis[[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methyl]phosphonate]
- EC Number:
- 265-512-0
- EC Name:
- Calcium diethyl bis[[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methyl]phosphonate]
- Cas Number:
- 65140-91-2
- Molecular formula:
- C17 H29 O4 P. 1/2Ca
- IUPAC Name:
- calcium diethyl bis[[[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]methyl]phosphonate]
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Russian breed
- Details on test animals or test system and environmental conditions:
- Weight: 1.5-2 kg
Diet: NAFAG, Gossau SG, rabbit food, ad libitum
Water: ad libitum
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- other: 50% polyethylene glycol
- Controls:
- no
- Amount / concentration applied:
- 0.5 g
- Duration of treatment / exposure:
- 24 h
- Observation period:
- 72 h
- Number of animals:
- 3 per sex
- Details on study design:
- TEST SITE
- Area of exposure: 2.5 cm x 2.5 cm
- Type of wrap if used: gauze patch covered with a plastic film
SCORING SYSTEM: Draize scheme
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24, 72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: intact skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24, 72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: intact skin
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24, 72 h
- Score:
- 0.3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Remarks on result:
- other: scarified skin
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24, 72 h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: scarified skin
- Irritant / corrosive response data:
- A mild erythema was observed in 4/6 animals at the 24 hour time point when tested on scarified skin (average score = 0.67), reversible within 72 hours. Intact skin did not elicit any reaction after treatment, all scores for edema and erythema were zero for all time points in all animals.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Conclusions:
- Based on the results of the study and under the test conditions chosen, the test article is considered to be not irritating to the rabbir skin.
- Executive summary:
In a skin irritation study three male and female rabbits were treated occlusively with the test article for 24 hours. The test article was applied to scarified and intact skin on the back of the rabbits on a gauze patch covered with a plastic film and held in place with an adhesive tape. 50% PEG served as vehicle. The reaction of the skin was appraised upon removal and 72 hours after. No scores were recorded for the 48 hour time point. All scores for the intact skin were zero for edema and erythema in all animals at any recorded time point. A mild erythema was observed in 4/6 animals at the 24 hour time point when tested on scarified skin (average score = 0.67), reversible within 72 hours. Findings on scarified skin have not been taken into account for the calculation of erythema and edema scores, due to current regulations according to which only findings on intact skin are reliable for assessing the skin irritation potential of a test substance. Based on the data provided by this study report, the test article is considered to be not irritating to rabbit skin.
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