Registration Dossier
Registration Dossier
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EC number: 233-038-3 | CAS number: 10025-73-7
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
The 9h-IC50 of chromium trichloride to the Protozoan (Tetrahymena pyriformis) was 50 mg Cr/L under test conditions, equivalent to 152.3 mg/L CrCl3 or 256 mg/L CrCl3.6H2O.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 256 mg/L
Additional information
The 9h-IC50 of chromium chloride to the Protozoan (Tetrahymena pyriformis) was 50 mg Cr/L under test conditions which is equivalent to 152.3 mg/L chromium trichloride (anhydrous) or 256 mg/L chromium trichloride hexahydrate.
The result were abstracted in Concise International Chemical Assessment Document 76 INORGANIC CHROMIUM(III) COMPOUNDS (2009), which was published by joint sponsorship of the United Nations Environment Programme, the International Labour Organization, and the World Health Organization, and produced within the framework of the Inter-Organization Programme for the Sound Management of Chemicals. Thus, the data can be assigned as the reliable with restrictions.
In this non-standard test with protozoa Tetrahymena pyriformis GL (TP) the cell number increase inhibition was monitored by adding organic and inorganic toxicant, one of them being chromium trichloride hexahydrate. Inhibition was recorded at 3, 6 and 9 hours exposure time representing 1, 2 and 3 cell generations. The IC50 value found in this study for chromium was 62, 54 and 50 mg/L following 3, 6 and 9 hours exposure respectively. Although testing versus protozoa is not a standard test model, the results published showed that the test model is capable of indicating cytotoxicity to aquatic organisms thus being useful to investigate inorganic and organic substances for their toxicological properties. The authors stated that "TP cultures must also be considered with great attention as an inexpensive tool for the screening study of chemical substances especially as their handling is rapid and simple. TP appeared to be more sensitive to some inorganic and organic substances. Moreover, TP is a real eukaryotic organism and therefore allowed the metabolism of organic substances to be studied."
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