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Diss Factsheets
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EC number: 204-130-0 | CAS number: 116-17-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No precision was indicated in the study report concerning the guideline followed
- GLP compliance:
- not specified
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Triisopropyl phosphite
- EC Number:
- 204-130-0
- EC Name:
- Triisopropyl phosphite
- Cas Number:
- 116-17-6
- Molecular formula:
- C9H21O3P
- IUPAC Name:
- tris(propan-2-yl) phosphite
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): Triisopropyl phosphite
- Sample number: 2090811
- Density: 0.90 g/mL
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- IN-LIFE DATES: From04-02-1982 to 24-02-1982
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: trunck
- Type of wrap if used: occlusive rubber dam
REMOVAL OF TEST SUBSTANCE
- Washing (if done): wiped with cotton wet with physiological saline
- Time after start of exposure: 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2g/kg
VEHICLE: No vehicle - Duration of exposure:
- 24 hours
- Doses:
- 2 g/kg
- No. of animals per sex per dose:
- 3 male and 3 female
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
+ Clinical observations: frequently on the day of treatment and the daily until the end of the study.
+ Assessment for irritation: 24h, 72h, D7, 10 and 14.
+ weighing: D0, 7 and 7
- Necropsy of survivors performed: no - Statistics:
- No
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 2 000 mg/kg bw
- Mortality:
- No death during the study
- Clinical signs:
- other: No clinicals sign observed
- Gross pathology:
- No
Any other information on results incl. tables
Animal |
Sex |
D0 BW (kg) |
Volume of dosing (mL) |
D7 BW (kg) |
D14 BW (kg) |
Skin irritation |
|||||||||
Day 1 |
Day 3 |
Day 7 |
Day 10 |
Day 14 |
|||||||||||
Erytema |
Edema |
Erytema |
Edema |
Erytema |
Edema |
Erytema |
Edema |
Erytema |
Edema |
||||||
242 (A) |
M |
2.6 |
5.4 |
2.8 |
3.1 |
1 |
0 |
1 |
1 |
1 |
1 |
1 |
1 |
0 |
0 |
244 (A) |
M |
2.7 |
5.9 |
2.7 |
2.8 |
1 |
0 |
1 |
0 |
1 |
0 |
1 |
0 |
0 |
0 |
281 (A) |
F |
2.6 |
5.4 |
2.7 |
3.0 |
1 |
2 |
1 |
2 |
1 |
1 |
1 |
0 |
0 |
0 |
248 (I) |
M |
2.6 |
5.4 |
2.7 |
2.9 |
2 |
2 |
1 |
2 |
1 |
1 |
1 |
0 |
0 |
0 |
284 (I) |
F |
2.4 |
5.2 |
2.6 |
2.8 |
2 |
2 |
2 |
2 |
1 |
1 |
1 |
0 |
1 |
0 |
282 (I) |
F |
2.4 |
5.2 |
2.6 |
2.7 |
2 |
2 |
1 |
2 |
1 |
1 |
1 |
0 |
0 |
0 |
(A) Abraded
(I) Intact
(BW): Body Weight
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information
- Conclusions:
- The dermal LD50 of the test material is judged greater than 2.0 g/kg.
- Executive summary:
The liquid test material was administered at a dose level of 2.0 g/kg to three male and 3 female New Zeland White rabbit. The hair was clipped from the entire trunk of each animal prior treatment. The skin, on three animalss ( 2 male 1 female) was abraded while the skin on the remaining three animals was left intact. Gauze and occlusive rubber dam covered the trunks of each animal. Immediately after treatment the animals were fitted with Elizabethan collars to restrcit contact with the test site. The animals were observed for signs of toxicity frequently on the day of treatment and daily thereafter for 14 days. After the initial 24 hours, the rabbits were unwrapped and the test sites wiped with cotton wet with physiological saline. The areas of application were assessed for irritation at 24 jourand 72 hours, 7, 10 and 14 days after treatment. After 14 days, the surviving animals were killed and discarded. There were no deaths after administration of the test compound. All animals gained weight throughout the study. There were no toxic signs observed in any of the animals during the study. All animals appeared normal.
The test material elicited signs of slight irritation in all rabbit. By day 14, there was barely perceptible irritation in one animal; all others were without irritation. There was flaking skin obseed on the tests sites of all animals on day 14.
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