Registration Dossier
Registration Dossier
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EC number: 201-163-2 | CAS number: 78-97-7
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study meets generally accepted scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
Materials and methods
- Objective of study:
- metabolism
- Principles of method if other than guideline:
- Method: other
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Automatically generated during migration to IUCLID 6, no data available
- IUPAC Name:
- Automatically generated during migration to IUCLID 6, no data available
- Details on test material:
- IUCLID4 Test substance: other TS
TS-Freetext:
Lactonitrile
Purity unknown
Constituent 1
Results and discussion
Toxicokinetic / pharmacokinetic studies
Toxicokinetic parametersopen allclose all
- Toxicokinetic parameters:
- half-life 2nd:
- Toxicokinetic parameters:
- half-life 1st:
- Toxicokinetic parameters:
- half-life 3rd:
Any other information on results incl. tables
RS-Freetext:
Mortality in mice following Lactonitrile treatment (0.26 mmol/kg) with inhibitors of ethanol metabolism or prostaglandin synthetase and a-Trocopherol
Treatment / mortality
-----------------------------------------------------------
Normal saline (1 ml/100 g) / 8/10
4-Methylpyrazole (125 mg/kg, ip) / 0/10*
Aspirin in water (80 mg/kg, ip) / 4/10
DMSO (5.5 g/kg, ip) / 2/10*
lndomethacin (2 mg/kg, ip) / 3/10*
Sodium salicylate in water (320 mg/kg, ip) / 9/10 a-Tocopherol (25 mg/kg ip in corn oil 25 hr and 1 hr
before cyanohydrins) / 8/10
a-Tocopherol (25 mg/kg ip in corn oil 25 hr before and
100 mg/kg 1 hr before cyanohydrins) / 8/10
-----------------------------------------------------------
* = Significance level p < 0.05
Cyanide release from Lactonitrile by yeast alcohol dehydrogenase (ug CN/ml)
Buffer / sub. conc. / + ADH / -ADH
-----------------------------------------------------------
Glycine (0.5M, pH9) / 1.97 mg/ml / 7.8 ± 0.9 / 5.3 ± 1.3
Glycine (0.5M, pH9) / 0.98 mg/ml / 5.3 ± 1.1 / 4.2 ± 1.6
Glycine (0.5M, pH9) / 0.49 mg/ml / 2.3 ± 1.2 / 0.3 ± 0.1
Glycine (0.5M, pH9) / 0.20 mg/ml / 0.8 ± 0.7 / -
Glycine (0.5M, pH9) / 0.10 mg/ml / 0.6 ± 0.5 / -
Phosphate (0.0Mm, pH7) / 0.98 mg/ml / 1.6 ± 0.2 / 2.1 ± 0.5
-----------------------------------------------------------
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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