Registration Dossier
Registration Dossier
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EC number: 700-445-7 | CAS number: 846023-54-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 21-29 October 2009
- Reliability:
- 1 (reliable without restriction)
Data source
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Qualifier:
- according to guideline
- Guideline:
- other: Japanese Ministry of Agriculture, Forestry and Fisheries (JMAFF), 12 Nousan, Notification No 8147, November 2000, including the most recent partial revisions.
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1-[3-(2-methoxy-5-nitrophenoxy)propyl]-4-methylpiperazine
- EC Number:
- 700-445-7
- Cas Number:
- 846023-54-9
- Molecular formula:
- C15H23N3O4
- IUPAC Name:
- 1-[3-(2-methoxy-5-nitrophenoxy)propyl]-4-methylpiperazine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Doses:
- 2000 mg/kg (10 mL/kg) body weight.
300 mg/kg (10 mL/kg) body weight.
Frequency: Single dosage, on Day 1. - Control animals:
- yes
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- >= 300 - <= 2 000 mg/kg bw
- Remarks on result:
- other: LD50 cut-off value was considered to be 500 mg/kg body weight.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- Migrated information: H302: Harmful if swallowed.
- Conclusions:
- Based on these results:
- according to the Globally Harmonized System of Classification and Labeling of Chemicals (GHS) of the United Nations (2007), WAY-190192-A should be classified as: harmful if swallowed (Category 4) for acute toxicity by the oral route.
- according to the Regulation (EC) No 1272/2008 on classification, labeling and packaging of substances and mixtures, WAY-190192-A should be classified as Category 4 and should be labeled as H302: Harmful if swallowed.
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