Registration Dossier
Registration Dossier
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EC number: 244-343-6 | CAS number: 21351-39-3
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- Target and source substances are highly similar, both structurally and chemically.
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- GLP compliance:
- no
- Dissociating properties:
- not determined
- Conclusions:
- An experimental determination of the dissociation constant according to the OECD guideline 112 is not possible.
Reference
In the preliminary test the UV/VIS absorption properties of the test item were investigated. Thus an aqueous solution of the test item with a concentration of c = 457 mg/l was prepared.
The test item in water (457 mg/l) shows a neglectable absorption of about 0.008 a. u. at 225 nm. Even after addition of sodium hydroxide no sufficient absorption was recorded. Also neutralizing with ammonium hydroxide led to no sufficiently detectable UV/VIS absorption.
According to the OECD Guideline 101 (UV/VIS Absorption Spectra) for the performance of a spectrophotometric method solutions should be prepared in a concentration which will result in an absorbance maximum in the range of 0.5 to 1.5 units (a. u.). Therefore it is scientifically not possible to perform the spectrophotometric method for the determination of the dissociation constant.
The titration method is not applicable for the determination of the dissociation constant. This is in accordance with the OECD Guideline 112.
Description of key information
An experimental determination of the dissociation constant according to the OECD guideline 112 is not possible.
Key value for chemical safety assessment
Additional information
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