Registration Dossier
Registration Dossier
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EC number: 209-750-5 | CAS number: 592-34-7
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Parent compound butyl chloroformate (CAS 592-34-7, rapidly hydrolyzing): Depending on local conditions and existing concentrations, disturbances in the biodegradation process of activated sludge are possible.
Hydrolysis product hydrogen chloride (HCL, CAS 7647 -01 -0): No data available
Hydrolysis product butanol (CAS 71 -36 -3): The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriately low concentrations.
Key value for chemical safety assessment
Additional information
Data for parent compound butyl chloroformate (CAS 592-34-7):
Study results acceptable as supporting data on the acute toxicity of butyl chloroformate (CAS 592-34-7) to microorganisms are available from a non-GLP study performed equivalently to a pre-guideline version of OECD 209. Industrial activated sludge was used as inoculum. The 180-min EC20 was determined to be ca. 70 mg/L (nominal; BASF AG, 1980).
However, the substance rapidly hydrolyses in contact with water to butanol (CAS 71 -36 -3), hydrogen chloride (HCL, CAS 7647 -01 -0) and carbon dioxide (CAS 124-38-9). The assessment is, therefore, additionally based on the available data of the hydrolysis products.
No data are available for the hydrolysis products hydrogen chloride (HCL, CAS 7647 -01 -0) and carbon dioxide (CAS 124-38-9).
Hydrolysis product – butanol (CAS 71-36-3):
For the hydrolysis product butanol (CAS 71-36-3) a number of study results are available. The key effect value is a 17-h EC10 of 2476 mg/L (nominal) as observed in a growth inhibition test with P. putida. The study was conducted according to DIN 38412 part 9 (BASF AG, 1990).Data from tests with the single species P. putida are to be used in terms of chemical safety assessment (CSA), if no other data are available.
Data from several further single-species tests are available for CAS 71-36-3 (summarized in OECD SIDS, 2001). However, according to REACH Guidance Chapter R.10 (ECHA, 2008) table R.10-6 toxicity, tests on micro-organisms in sewage treatment plants (STP) based on single species (besides P. putida) according to methods of Bringmann & Kühn are of limited relevance for STP functioning. These data are, therefore, disregarded in terms of CSA. The only test results with P. putida summarized in the OECD SIDS (2001) revealed a 16-h TTC of 650 mg/L, supporting the data of the key study; the toxic threshold concentration (TTC) was defined and calculated by the authors on the basis of the extinction values of the test samples. In short, the TTC is similar to a 3%-effect concentration (EC3).
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