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EC number: 800-696-3 | CAS number: 78605-96-6
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Recent GLP study to current guidlines
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- Shaken at 30 C and stood at 20 C for a shorter period to address an observed reduction in analysed concentration with longer shaking times.
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Water solubility:
- > 0.547 - < 4.09 mg/L
- Temp.:
- 20 °C
- pH:
- ca. 3.9
- Conclusions:
- Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
The water solubility of the test item has been determined to be at least 4.09x10-3 g/L of solution at 20 +/- 0.5 degrees C. However, this concentration was only achieved using an amended procedure with significantly reduced saturation and equilibrium time periods. The test item was shown to be unstable under the standard test guidlenes conditions.
Reference
Sample Number |
Time shaken at 30°C (hours) |
Time equilibrated at 20°C (hours) |
Concentration (g/L) |
Solution pH |
1A |
24 |
24 |
9.30x10-4 |
3.91 |
1B |
24 |
24 |
9.20x10-4 |
3.91 |
2A |
48 |
24 |
6.23x10-4 |
3.78 |
2B |
48 |
24 |
6.09x10-4 |
3.78 |
3A |
72 |
24 |
6.07x10-4 |
3.76 |
3B |
72 |
24 |
5.47x10-4 |
3.76 |
4A |
1 |
1 |
3.81x10-3 |
3.99 |
4B |
1 |
1 |
4.09x10-3 |
3.99 |
5A |
2 |
1 |
2.90x10-3 |
4.09 |
5B |
2 |
1 |
3.00x10-3 |
4.09 |
6A |
3 |
1 |
2.39x10-3 |
4.10 |
6B |
3 |
1 |
2.27x10-3 |
4.10 |
|
|
|
Range: 5.47x10-4 to 4.09x10-3. Overall result: at least 4.09x10-3 g/L at 20±0.5°C |
Average = 3.94 |
Description of key information
The water solubility of the test item has been determined to be at least 4.09x10-3 g/L of solution at 20 +/- 0.5 degrees C. However, this concentration was only achieved using an amended procedure with significantly reduced saturation and equilibrium time periods. The test item was shown to be unstable under the standard test guideline conditions.
Key value for chemical safety assessment
- Water solubility:
- 4.09 mg/L
- at the temperature of:
- 25 °C
Additional information
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