Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

NMDA is a strongly caustic amine which is almost fully dissociated in water. pH values of 12 can be expected from a solution of only 2 % (w/w). No in vivo studies are necessary. The substance is classified as corrosive.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vitro / ex vivo
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study need not be conducted because the substance is a strong acid (pH <= 2.0) or base (pH => 11.5)
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (corrosive)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vitro / ex vivo
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
the study need not be conducted because the substance is a strong acid (pH <= 2.0) or base (pH => 11.5)
Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irreversible damage)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

The acute skin irritation properties of NMDA were estimated from the corrosive properties as determined in a pH test of solutions. Also the oral toxicity study resulted in hemorrhage in stomach and intestine which are signs of a strongly corrosive (alkaline) preparation.

It is considered that performing irritancy studies via the dermal or ocular routes are unlikely to yield any additional data to those already available.

Justification for classification or non-classification

The corrosive properties and the pH of >12 of the isomeric substance 2 -methyl-octyldiamine MODA support the classifications:

  • following regulation (EC) No 1272/2008: Skin Corr. 1B; H314, "causes severe skin burns and eye damage";
  • following directive 67/548/EEC: C, corrosive; R35, "causes severe burns"