Registration Dossier
Registration Dossier
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EC number: 237-253-3 | CAS number: 13709-42-7
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
24 and 48 hour EC₅₀ of > 100 % v/v saturated solution (Daphnia magna). 24 and 48 hour NOEC 100 % v/v saturated solution. The study demonstrated that there were no toxic effects at saturation.
Key value for chemical safety assessment
Additional information
A study was performed to assess the acute toxicity of the test material to Daphnia magna. The method followed was designed to be compatible with the OECD Guidelines for Testing of Chemicals (April 2004) No 202, “Daphnia sp., Acute Immobilisation Test” references as Method C.32 of Commission Regulation (EC) No. 440/2008. The study was conducted in line with GLP and was well reported. It was therefore assigned a reliability score of 1 in accordance with the criteria defined in Klimisch (1997).
Due to the poor water solubility of the test material, a saturated solution method of preparation was most appropriate for the test material. It was determined that a “limit test” was appropriate following the outcome of a preliminary range-finding test. Twenty daphnids (4 replicates of 5 animals) were exposed to an aqueous solution of the test item at a concentration of 100 % v/v saturated solution for 48 hours at a temperature of 20 °C to 21 °C under static test conditions. Immobilisation and any adverse reactions to exposure were recorded after 24 and 48 hours.
Under the conditions of the test, the acute toxicity of the test material to the freshwater invertebrate Daphnia magna gave a 24 and 48 hour EC₅₀ of > 100 % v/v saturated solution. The No Observed Effect Concentration at 24 and 48 hours was determined to be 100 % v/v saturated solution. The study demonstrated that there were no toxic effects at saturation.
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