Registration Dossier
Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 214-770-2 | CAS number: 1193-21-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study acceptable for assessment, basic data given
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- yes
- GLP compliance:
- yes
- Type of study:
- other: LLNA; proceeding not described in detail
Test material
- Reference substance name:
- 4,6-dichloropyrimidine
- EC Number:
- 214-770-2
- EC Name:
- 4,6-dichloropyrimidine
- Cas Number:
- 1193-21-1
- Molecular formula:
- C4H2Cl2N2
- IUPAC Name:
- 4,6-dichloropyrimidine
Constituent 1
In vivo test system
Test animals
- Species:
- other: no data
- Strain:
- other: no data
- Sex:
- not specified
Study design: in vivo (LLNA)
- Vehicle:
- dimethyl sulphoxide
- Concentration:
- Vehicle only
0.1 % w/v
0.3 % w/v
1.0 % w/v - No. of animals per dose:
- no data
Results and discussion
Any other information on results incl. tables
Concentration of test material CPM/Lymph Test/Control Ratio
node (x10 -2)
Vehicle only (DMSO) 1.48 --
0.1 % w/v 2.06 1.4
Vehicle only (DMSO) 2.45 --
0.3 % w/v 10.47 4.3
1.0 % w/v 16.93 6.9
Additional concentrations of 0.3 and 1 % w/v of the TS were dosed with a corresponding control group to confirm any sensitization response.
The incorporation of radioactive material is given as counts per minute/Lymph node x 10 -2 and the Stimulation Index (SI) as Test/Control Ratio.
For the higher concentrations (0,3 % and 1,0 %) in DMSO an SI exceeding the value of 3 was obtained (4,3 and 6,9; respectively).
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information
- Conclusions:
- Only a very short summary of the study is available. No details on study design or performance are reported. Based on the data given the TS should
be regarded as a potential skin sensitizer at concentrations of 0.3 % and 1.0 %.
Therefore the TS is classified as Xi, R 43 (may cause sensitization by skin contact)
Although it is likely that the design of this study does not fulfill the requirements of OECD 429 ("Skin sensititisation: Local Lymph Node Assay") and only a very short summary of the report is available instead of a complete report, the study may be regarded as valid with restrictions (Klimisch 2, basic data given) and used for assessment if 4,6-dichloropyrimidine is classifled as Xi; R43 (may cause sensitization by skin contact) for precautionary reasons as the results of study are not surprising or unexpeded. No new study should be performed due to animal welfare.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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