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EC number: 856-079-4 | CAS number: 55860-35-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Density
Administrative data
- Endpoint:
- bulk density
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 109 (Density of Liquids and Solids)
- Version / remarks:
- 2012
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- air comparison pycnometer (for solids)
Test material
- Reference substance name:
- 4-acetyl-2-methylbenzoic acid
- EC Number:
- 856-079-4
- Cas Number:
- 55860-35-0
- Molecular formula:
- C10H10O3
- IUPAC Name:
- 4-acetyl-2-methylbenzoic acid
- Test material form:
- solid: particulate/powder
Constituent 1
Results and discussion
Density
- Key result
- Type:
- bulk density
- Density:
- 1.35 g/cm³
- Temp.:
- 20 °C
Any other information on results incl. tables
The density of the test substance was determined with the gas comparison pycnometer method. A Multi-Pycnometer from Quantochrome (Syosset, USA) was used in this study. The instrument can be pressurised with helium and consists of two interlinked reference and sample cells of fixed volume. The volumes of the two cells were confirmed prior to the test through the use of a stainless steel calibration sphere of certified volume. The sample analysis was then performed by recording the pressure drop for the pressurised reference cell when the additional volume of the sample cell containing an accurately weighed aliquot of test substance was added, from which the volume of the test substance could be accurately calculated. The volume of the reference cell was determined from four pressure readings obtained in the calibration procedure with the stainless steel calibration sphere. Aliquots of the test substance of 20.5794 and 21.3753 g were weighed into the sample cell and placed into the pycnometer. Triplicate pressure pressure readings were taken after pressurising the reference cell of known voume and then switching to the sample cell. The reference cell and sample cell volumes were within the defined tolerance (90.953 ± 1.0 cm3 and 149.225 ± 1.0 cm3) and the gas comparison pycnometer was considered acceptable for use. The overall mean density was determined to be 1.35 g/cm3.
Table 1: Gas comparison pycnometer calibration results
Replicate | P1 (psig) | P2 (psig) | P3 (psig) | P4 (psig) | Reference cell volume (cm3) | Sample cell volume (cm3) |
1 | 17.150 | 6.496 | 17.033 | 8.439 | 90.972 | 149.202 |
2 | 17.038 | 6.457 | 17.063 | 8.456 | 91.102 | 149.288 |
3 | 17.058 | 6.465 | 17.035 | 8.444 | 91.062 | 149.206 |
Table 2: Measurement results for test substance
Determination | Test | P1 (psig) | P2 (psig) | Volume (cm3) | Density (kg/m3) |
1 | A | 17.078 | 6.907 | 15.162 | 1.36 E03 |
1 | B | 17.124 | 6.927 | 15.207 | 1.35 E03 |
1 | C | 17.009 | 6.879 | 15.159 | 1.36 E03 |
2 | A | 17.003 | 6.895 | 15.760 | 1.36 E03 |
2 | B | 17.104 | 6.938 | 15.827 | 1.35 E03 |
2 | C | 17.056 | 6.918 | 15.809 | 1.35 E03 |
Applicant's summary and conclusion
- Conclusions:
- The mean density of the substance was determined to be 1.35 g/cm3 at 20 °C.
- Executive summary:
The density of the substance was determined under GLP to OECD TG 109 using the gas comparison pycnometer method. The density of the test substance was determined with the gas comparison pycnometer method. A Multi-Pycnometer from Quantochrome (Syosset, USA) was used in this study. The instrument can be pressurised with helium and consists of two interlinked reference and sample cells of fixed volume. The volumes of the two cells were confirmed prior to the test through the use of a stainless steel calibration sphere of certified volume. The sample analysis was then performed by recording the pressure drop for the pressurised reference cell when the additional volume of the sample cell containing an accurately weighed aliquot of test substance was added, from which the volume of the test substance could be accurately calculated. The volume of the reference cell was determined from four pressure readings obtained in the calibration procedure with the stainless steel calibration sphere. Aliquots of the test substance of 20.5794 and 21.3753 g were weighed into the sample cell and placed into the pycnometer. Triplicate pressure pressure readings were taken after pressurising the reference cell of known voume and then switching to the sample cell. The reference cell and sample cell volumes were within the defined tolerance (90.953 ± 1.0 cm3 and 149.225 ± 1.0 cm3) and the gas comparison pycnometer was considered acceptable for use. The overall mean density of the test substance was determined to be 1.35 g/cm3.
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