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EC number: 268-211-2 | CAS number: 68037-36-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- other: Method Development
- Adequacy of study:
- other information
- Study period:
- 18 October 2017
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A hydrolysis trial was conducted in order to determine whether a suitable analytical method could be utilised in order to the measure the hydrolysis of the test material in relation to pH.
As the test material is a UVCB, a surrogate ICP methodology was previously developed and implemented for the determination of the solubility of the test material. For the hydrolysis study, the copper surrogate methodology, where all copper containing components are collectively measured as an integrated total copper response, would not have been capable of distinguishing between parent compound and hydrolysis products. Therefore, a hydrolysis trial was conducted using pH measurement and changes in pH as a possible surrogate indicator of hydrolysis, where the generated of protons essentially serves as a potential measure of possible parent degradation.
Solutions of the test material was prepared in pH 5, 7 and 9 buffers at concentration of 1.8, 1.8 and 2.0 mg/L, respectively. A light was shone through each solution during the test period (six days) to observe Tyndall effect in the solutions. This was also repeated after sonicating aliquots for 20 minutes. Aliquots were also centrifuged at very high speed.
An aliquot of each solutions was taken for initial (Day 0) pH measurement. Portions of each solution were decanted to glass vials, filling each to minimise headspace. The vessels were then sealed. The vials were placed in darkness in an incubator set to 50 °C. At each sampling interval (Day 1, 2, 3 and 6) a vial at each pH was removed from the incubator, allowed to cool to room temperature and the pH measured. - GLP compliance:
- not specified
- Radiolabelling:
- not specified
- Analytical monitoring:
- no
- Details on sampling:
- - Sampling intervals/times for pH measurements: Days 1, 2, 3 and 6
- Other observation, if any (e.g.: precipitation, color change etc.): Tydall effect observations were made throughout the study - Buffers:
- - pH: 4, 7 and 9
- Details on results:
- Tyndall effect was evident when shining a light through each solution at test initiation. This effect was noted after day 6 and after sonicating aliquots for 20 minutes. Tyndall effect was only eliminated after high speed centrifugation (23000 x g for 20 minutes). The hydrolysis trial test concentrations were deemed appropriate for this test material in buffers based on the solubility data in reagent water. It was expected that reducing the concentrations would have mitigated measurement of potential pH changes caused by hydrolysis.
The measured pH values do not show any apparent pattern or trend. Based on these results, pH was deemed not to be a suitable indicator of hydrolytic degradation. - Validity criteria fulfilled:
- no
- Conclusions:
- Several hydrolytic degradation methods were developed, copper surrogate and pH, but neither method was a suitable indicator of hydrolytic degradation of the test substance.
- Executive summary:
A hydrolysis trail was conducted to investigate the feasibility of using pH measurement to assess hydrolytic degradation of the test substance. Due to the complex nature of the UVCB substance, a copper surrogate ICP methodology was previously developed and implemented for the determination of the solubility of the test item. However, for a hydrolysis study this copper surrogate methodology, where all copper containing components were collectively measured as an integrated total copper response, would not be capable of distinguishing between parent compound and components and hydrolytic degradation products. Therefore, it was determine that pH measurement and changes in pH was a possible potential measure of possible parent degradation. Several pH values were used during sampling days 1, 2, 3, and 6. The pH values did not show any apparent patterns or trends. Based on these values, pH was deemed not a suitable indicator of hydrolytic degradation of the test substance.
Reference
Table 1: Results of pH measurements
Sampling Interval |
Measured pH |
||
pH 5 Buffer |
pH 7 Buffer |
pH 7 Buffer |
|
0 (initiation) |
5.05 |
7.15 |
9.12 |
1 |
5.09 |
7.17 |
9.07 |
2 |
5.08 |
7.16 |
9.06 |
3 |
5.05 |
7.18 |
9.08 |
6 |
5.07 |
7.19 |
9.10 |
Description of key information
A hydrolysis trail was conducted to investigate the feasibility of using pH measurement to assess hydrolytic degradation of the test substance. Due to the complex nature of the UVCB substance, a copper surrogate ICP methodology was previously developed and implemented for the determination of the solubility of the test item. However, for a hydrolysis study this copper surrogate methodology, where all copper containing components were collectively measured as an integrated total copper response, would not be capable of distinguishing between parent compound and components and hydrolytic degradation products. Therefore, it was determine that pH measurement and changes in pH was a possible potential measure of possible parent degradation. Several pH values were used during sampling days 1, 2, 3, and 6. The pH values did not show any apparent patterns or trends. Based on these values, pH was deemed not a suitable indicator of hydrolytic degradation of the test substance.
Key value for chemical safety assessment
Additional information
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