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EC number: 268-211-2 | CAS number: 68037-36-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- June 8, 2017 to August 17, 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- flask method
- Key result
- Water solubility:
- 92.9 mg/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 1 g/L
- Incubation duration:
- 24 h
- Temp.:
- 20 °C
- pH:
- 6.5
- Details on results:
- The measured concentration of the test substance was calculated as follows:
Copper in sample (mg a.i./L) = ((Mean corrected intensity – (Y-intercept))/ slope) x Dilution factor
Mean corrected intensity = 2042.6
Y-intercept = -27.35
Slope = 4500.5000
First initial volume (Vil) = 5.00 mL
First final volume (Vfl) = 10.0 mL
Second initial volume (Vi2) = 1.00 mL
Second final volume (Vf2) = 10.0 mL
Dilution factor = (Vfl/Vil) x *(Vf2/Vi2) = (10.0/5.00) x (10.0/1.00) = 20.0
Copper in sample (mg a.i./L) =((2042.6 – (-27.35))/4500.5000) x 20.0
Copper in sample (mg a.i./L) = 9.20
Sample (mg/L) copper in sample/copper in test material
Sample (mg/L) = 9.20/9.11 % = 101
Based on the preliminary trial, the water solubility of the test material after the 24-hour shake flask test at 20 20C was determined to be approximately 130 mg/L. Based on this finding, the target concentration was determined to be 1.0 mg/L for the definitive test.
The pH of the test system and samples was evaluated concurrent with the definitive test. The pH of the test system (reagent) water at 20 °C was 6.50. The measured pH of the supernatant of reagent water saturated with the test substance at 20 °C was 6.5 for both the 24 and 48-hour samples.
Mean measured water-soluble test substance concentrations for saturations samples shaken and equilibrated at 30 °C for 24 and 48 hours prior to equilibration at 20 °C were 0.033 % (within the 15 % required for the protocol). The mean water solubility of the test material was determined to be 92.9 ± 4.2 mg/L (CV = 4.5 %) at 20 °C. - Conclusions:
- The water solubility of the test substance in reagent water at 20 °C was determined using the shake flask method. The overall mean water solubility for the test substance at 20.0 ± 0.1 °C was determined to be 92.9 ± 4.2 mg/L (N = 6; CV = 4.5%).
- Executive summary:
The water solubility of the test substance in reagent water at 20 °C was determined using the shake flask method. The test was performed based on procedures in the U.S. EPA Product Properties Test Guidelines, OPPTS 830.7840, Water Solubility: Column Elution Method; Shake Flask Method (1) and OECD Guideline for the Testing of Chemicals, 105: Water Solubility. The definitive shake flask test consisted of equilibrating an excess amount of test substance with water at an elevated temperature, 30 °C, followed by an equilibration at 20 °C. A preliminary test was done prior to the definitive portion to estimate the solubility by a physical dissolution test. The overall mean water solubility for the test substance at 20.0 ± 0.1 °C was determined to be 92.9 ± 4.2 mg/L (N = 6; CV = 4.5 %).
Reference
Table 1: Definitive water solubility of the test material at 20 °C
Sample |
Time at 30 °C (hrs) |
Concentration of test material |
%Difference |
||
Nominal (mg/mL) |
Measured (mg/L) |
Mean measured ± SD (mg/L) |
|||
1-1 |
24 |
1 |
101 |
94.4 ± 5.9 (CV = 6.3 %) |
0.033 % |
1-2 |
24 |
1 |
92.8 |
||
1-3 |
24 |
1 |
89.5 |
||
2-1 |
48 |
1 |
91.1 |
91.4 ± 1.5 (CV = 1.7) |
|
2-2 |
48 |
1 |
90.0 |
||
2-3 |
48 |
1 |
93.0 |
||
Overall mean |
92.9 |
||||
SD |
4.2 |
||||
CV |
4.5 |
||||
N |
6 |
||||
SD = Standard deviation |
Description of key information
The water solubility of the test substance in reagent water at 20ºC was determined using the shake flask method. The overall mean water solubility for the test substance at 20.0 ± 0.1°C was determined to be 92.9 ± 4.2 mg/L (N = 6; CV = 4.5 %).
Key value for chemical safety assessment
- Water solubility:
- 92.9 mg/L
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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